CXCL11

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CXCL11

A gene on chromosome 4q21 that encodes a CXC-type chemokine that is chemotactic for IL-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. CXCL11 induces calcium release in activated T-cells, binds to CXCR3 and may play an important role in CNS diseases involving T-cell recruitment. It may also play a role in cutaneous immune responses.
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Osunkoya, MD, Department of Pathology, Emory University School of Medicine, 1364 Clifton Rd, NE, Suite H174, Atlanta, GA 30322 (email: adeboye.osunkoya@emory.edu).
H80 Kyocera Fineceramics GmbH H59 L-3 Communications, Telemetry West H174 Labtech Ltd.
We applied this protocol to quantification of mRNA expression of the following immunorelevant genes: interleukin (IL)-1[alpha], IL-1[beta], IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p40, IL-18, tumor necrosis factor-[alpha] (TNF-[alpha]), interferon-[gamma] (IFN-[gamma]), macrophage-inducing protein-3[alpha] (MIP-3[alpha]), SCYB-11 (IFN-inducible T-cell-[alpha] chemoattractant; H174; CXCL11), intracellular adhesion molecule-1 (ICAM-1; CD54), and nuclear factor-[kappa]B (NF[kappa]B), the transcription factor and central mediator of immune response.