# alternative hypothesis

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## hypothesis

[hi-poth´ĕ-sis]a supposition that appears to explain a group of phenomena and is advanced as a bases for further investigation.

**alternative hypothesis**the hypothesis that is formulated as an opposite to the null hypothesis in a statistical test.

**complex hypothesis**a prediction of the relationship between two or more independent variables and two or more dependent variables.

**directional hypothesis**a statement of the specific nature (direction) of the relationship between two or more variables.

**Lyon hypothesis**a hypothesis about development of X chromosomes in the embryo; see lyon hypothesis.

**Monro-Kellie hypothesis**[mun-ro´ kel´e] an explanation of the maintenance of intracranial pressure: The skull is viewed as a closed container housing brain tissue, blood, and cerebrospinal fluid; a change in any of these three components will affect the other two. If the volume added to the cranial vault is equal to the volume displaced, the intracranial volume will not change.

**nondirectional hypothesis**a statement that a relationship exists between two variables, without predicting the exact nature (direction) of the relationship.

**null hypothesis**the hyothesis that the effect, relationship, or other manifestation of variables and data under investigation does not exist; an example would be the hypothesis that there is no difference between experimental and control groups in a clinical trial.

**hypothesis test**the abstract procedure that is the theoretical basis of most statistical tests. A hypothesis test decides between two hypotheses, the

*null hypothesis*(

*H*

_{0}) that the effect under investigation does not exist and the

*alternative hypothesis*(

*H*

_{1}) that some specified effect does exist, based on the observed value of a

*test statistic*whose sampling distribution is completely determined by

*H*

_{0}. The decision is made to reject

*H*

_{0}and by implication to accept

*H*

_{1}when the test statistic falls within a given set of values called the

*critical region.*This region is so determined that the probability of rejecting

*H*

_{0}when it is in fact true (a so-called

*Type I error,*the reporting as significant results that are only the result of random variation and not a real effect), is set at a specified level (symbol α). When this level is set before the data are collected, usually at 0.05 or 0.01, it is called the

*significance level*or

*α level*. It is now more common to report the smallest α at which the null hypothesis can be rejected; this is called the

*significance probability*or

*P value*. The ability of the test to accept a true alternative (and thus to detect a real effect when it exists) is termed the

*power*of the test. Note that no statistical test actually tests the

*H*

_{1}.

Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

## al·ter·na·tive hy·poth·e·sis

in Neyman-Pearson testing of a hypothesis, the hypothesis or family of hypotheses about the numerical value of a parameter if and only if the null hypothesis is rejected as untenable.

Farlex Partner Medical Dictionary © Farlex 2012

## alternative hypothesis

EBMA statement that the means, variance, etc., of the samples being tested are not equal, which is the opposite of a null hypothesis.

Epidemiology

A hypothesis to be adopted if a null hypothesis proves implausible, where exposure is linked to disease.

Oncology

A hypothesis of tumour biology which holds that cancer is a systemic disease for which locoregional therapy is unlikely to improve survival statistics.

Statistics

A statement which is true if the null hypothesis is false; the type of test—left, right or two-tail—is based on the alternative hypothesis.

Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

## alternative hypothesis

Epidemiology A hypothesis to be adopted if a null hypothesis proves implausible, where exposure is linked to disease. See Hypothesis testing. Cf Null hypothesis.McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

## alternative hypothesis

The possibility (which should always be borne in mind) that an explanation of a phenomenon or result, however apparently obvious, may not be correct. See also NULL HYPOTHESIS.Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

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