Gwt1 | definition of Gwt1 by Medical dictionary
PIGW (redirected from Gwt1)
PIGW A gene on chromosome 17q12 that encodes a probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol. PIGW is involved in glycolipid and glycosylphosphatidylinositol-anchor biosynthesis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
According to the company, APX001A, the active moiety of APX001, inhibits the highly conserved fungal enzyme Gwt1
, compromising growth of major fungal pathogens.
Gepinacin and E1210 were found to inhibit the fungal acyltransferase Gwt1
, impairing the growth of fungal pathogens.
APX001 is the prodrug of APX001A, which is a first-in-class small molecule drug candidate that inhibits the highly conserved fungal enzyme Gwt1
, compromising growth of major fungal pathogens, including Candida and Aspergillus.