PIGW

(redirected from Gwt1)

PIGW

A gene on chromosome 17q12 that encodes a probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol. PIGW is involved in glycolipid and glycosylphosphatidylinositol-anchor biosynthesis.
References in periodicals archive ?
According to the company, APX001A, the active moiety of APX001, inhibits the highly conserved fungal enzyme Gwt1, compromising growth of major fungal pathogens.
Gepinacin and E1210 were found to inhibit the fungal acyltransferase Gwt1, impairing the growth of fungal pathogens.
APX001 is the prodrug of APX001A, which is a first-in-class small molecule drug candidate that inhibits the highly conserved fungal enzyme Gwt1, compromising growth of major fungal pathogens, including Candida and Aspergillus.