Guthrie test(redirected from Guthrie tests)
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a screening tool used with infants to determine the level of phenylalanine in the blood. Blood from the head is placed on filter paper, which is then placed on agar plates with a strain of Bacillus subtilis that requires phenylalanine for growth. If there is excessive phenylalanine in the blood sample, a halo will form around the filter paper, and additional tests are required to determine the seriousness of the hyperphenylalaninemia.
bacterial inhibition assay for direct measurement of serum phenylalanine; in widespread use for detection of phenylketonuria in the newborn.
Guth·rie test(gŭth'rē test)
Bacterial inhibition assay for direct measurement of serum phenylalanine; in widespread use for detection of phenylketonuria in the newborn.
Guthrie testA sensitive test for PHENYLKETONURIA that can be done on the new-born baby. The test requires a few drops of blood from a heel stab and the blood is then cultured with bacteria that grow well in an environment of phenylalanine. Heavy growth indicates an abnormal concentration of the substance. (Clyde Graeme Guthrie, 1880–1931, American physician).
Guthrie,Robert, U.S. pediatrician, 1916–.
Guthrie test - bacterial inhibition assay for detection of phenylketonuria in the newborn.