Guthrie test


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Guthrie test

 [guth´re]
a screening tool used with infants to determine the level of phenylalanine in the blood. Blood from the head is placed on filter paper, which is then placed on agar plates with a strain of Bacillus subtilis that requires phenylalanine for growth. If there is excessive phenylalanine in the blood sample, a halo will form around the filter paper, and additional tests are required to determine the seriousness of the hyperphenylalaninemia.

Guth·rie test

(gŭth'rē),
bacterial inhibition assay for direct measurement of serum phenylalanine; in widespread use for detection of phenylketonuria in the newborn.

Guth·rie test

(gŭth'rē test)
Bacterial inhibition assay for direct measurement of serum phenylalanine; in widespread use for detection of phenylketonuria in the newborn.

Guthrie test

A sensitive test for PHENYLKETONURIA that can be done on the new-born baby. The test requires a few drops of blood from a heel stab and the blood is then cultured with bacteria that grow well in an environment of phenylalanine. Heavy growth indicates an abnormal concentration of the substance. (Clyde Graeme Guthrie, 1880–1931, American physician).

Guthrie,

Robert, U.S. pediatrician, 1916–.
Guthrie test - bacterial inhibition assay for detection of phenylketonuria in the newborn.
References in periodicals archive ?
As well as giving police the breakthrough DNA match on the knife, the Guthrie Test card was crucial in another aspect of the case.
But he said the Guthrie Test archive could not turn into an "unofficial database" of DNA samples.
Robert Guthrie and the Guthrie Test: Devised in 1962 by physician and bacteriologist, Robert Guthrie for detecting phenylketonuria (PKU) in newborns, the Guthrie test represents the medical profession's first foray into newborn screening based on a tiny blood sample gathered through a heel prick when a baby is only two to three days old.
In addition, the neonatal Guthrie test cards of both patients were traced back, and the concentrations of acylcarnitines were also determined in these samples.
Guthrie's screen for MSUD is still used by many states, but Texas doesn't use the Guthrie test, either.
1) and its area (Table 1) show that the Guthrie test has a slightly higher value (0.9982) than the Wallac and Isolab kits, but the difference in area is not statistically significant (P = 0.16).
But Vicky's Guthrie test - a procedure which used to be performed on all babies - had been kept.
A THE midwife probably performed a heel prick or Guthrie test. The blood sample is used to test for some or all of these disorders - phenylketonuria, congenital hypothyroidism, cystic fibrosis, MCAD deficiency and sickle cell disease.
The Guthrie test, based on a blood spot on filter paper from a heelstick (a method of obtaining blood samples from newborns by pricking the heel) and bacterial assays (tests), required a separate test for each disorder although the same blood spot could be used.
Then two weeks later he had a Guthrie test and was diagnosed as having phenylketonuria (PKU).
Guthrie tested by using blood samples on filter paper obtained by pricking a newborn baby's heel to get a few drops of blood.