GHR

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GHR

A gene on chromosome 5p13-p12 that encodes growth hormone receptor, a type-I cytokine receptor which, once GH is bound, dimerizes and activates the JAK2/STAT5 transduction pathway, leading to growth.

Molecular pathology
Defects in GHR cause Laron type dwarfism.
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References in periodicals archive ?
The extracellular domain of the growth hormone receptor interacts with coactivator activator to promote cell proliferation.
Mechanism of activation of protein kinase JAK2 by the growth hormone receptor. Science, 344: 1249783.
New insights in genomic organization and heterogeneity of growth hormone receptors. Fish Physiol.
Growth regulation in the gobiid teleost, Gillichthys mirabilis: roles of growth hormone, hepatic growth hormone receptors and insulin-like growth factor-I.
Monoclonal antibodies to the rabbit liver growth hormone receptor: Production and characterization.
After GH binding to growth hormone receptor (GHR), tyrosine kinase janus kinase 2 (JAK2) is activated, which in turn phosphorylates multiple tyrosines within both itself and the GH receptor, as well as multiple signalling pathways.
GH activity can be regulated at the level of growth hormone receptor (GHR) or intracellular signal transduction and with catabolic situations such as parturition, malnutrition, infection and disease occurrence may lead to a state of GH resistance (Kopchick and Andry, 2000; Lucy et al., 2001; Zhu et al., 2001; Kim and Boisclair et al., 2008).
Dysfunctional growth hormone receptor in a strain of sex-linked dwarf chicken: evidence for mutation in the intracellular domain.
The total RNA was extracted from adipose tissue to measure the abundance of the chicken growth hormone receptor (cGHR), insulin-like growth factor 1 (cIGF-1), insulin-like growth factor I receptor (cIGF-IR), peroxisome proliferator-activated receptor gamma (cPPAR[gamma]), cAdiponectin and cAdipoIR mRNA by RT-PCR using [beta]-actin as an internal standard.
The growth hormone-binding protein in rat serum is an alternatively spliced form of the rat growth hormone receptor. Genes Dev.

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