GRB2

(redirected from Growth factor receptor-bound protein 2)

GRB2

A gene on chromosome 17q24-q25 that encodes an adaptor protein which provides a critical link between cell surface growth factor receptors and the Ras-signalling pathway, and may play a role in apoptosis.
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Many of these proteins act as adapter molecules, such as the p85 regulatory subunit of PI3K or Grb2 (growth factor receptor-bound protein 2).
In the case of ERK, the activation through these receptors leads to the recruitment of downstream effectors including growth factor receptor-bound protein 2 (Grb2) and protein tyrosine phosphatase non-receptor type 11 (PTPN11/Shp2), leading to the recruitment of Gab1 (GRB2-associated binding protein 1) and SOS (Son of Sevenless).