It had been demonstrated that as many as 403 amino acids within the nsp2 hypervariable region were dispensable for viral viability in vitro  and the selected nsp2 gene deletion mutations could delay seroconversion and growth attenuation
in swine .
The treatment included growth attenuation
via estrogen therapy, hysterectomy, and bilateral breast bud removal.
To the Editor: In the November-December 2010 issue, the Seattle Growth Attenuation and Ethics Working Group ("Navigating Growth Attenuation in Children with Profound Disabilities") analyzed the arguments for and against growth attenuation in children with permanent, profound intellectual disabilities and identified conditions under which its use may be ethically acceptable.
The group focused on growth attenuation rather than on the broader "Ashley Treatment," which also included a hysterectomy and breast bud removal.
Growth attenuation treatment for children such as Ashley challenges us to think beyond our initial reactions.
Growth attenuation through high dose estrogen therapy hastens the normal impact of puberty on girls' height.
To the Editor: As the lawyer representing the hospital involved in the Ashley case, I write to offer my profound thanks to the Seattle Growth Attenuation
and Ethics Working Group for their thorough, thoughtful, balanced, and considerate analysis in "Navigating Growth Attenuation
in Children with Profound Disabilities" (Nov-Dec 2010).
I was invited to join the Seattle Growth Attenuation
and Ethics Working Group--collective author of the lead article in this issue of the Report--but I begged off, claiming I had too many other things on my plate.
A twenty-person working group convened to discuss the ethical and policy considerations of the controversial intervention called "growth attenuation
," and if possible to develop practical guidance for health professionals.
In other bioethics contexts, such as decisions on life-sustaining treatment, sterilization, and growth attenuation
, disability advocates have charged that support for parental and family decision-making necessarily includes acceptance of decisions based on eugenic and social-worth considerations.
(1.) This bundle of interventions was described in detail at the University of Washington's May 16, 2007, Growth Attenuation
The term "growth attenuation
" referred to several standard estrogen contraceptive patches being used together to accelerate puberty and close the long bones' epiphyseal growth plates.