Grover disease

tran·sient a·can·tho·lyt·ic der·ma·to·sis

a pruritic papular eruption, with histologic suprabasal acantholysis, of the chest, with scattered lesions of the back and lateral aspects of the extremities, lasting from a few weeks to several months; seen predominantly in males over 40.
Synonym(s): Grover disease

tran·si·ent a·can·tho·lyt·ic der·ma·to·sis

(tran'sē-ĕnt a-kan'thŏ-lit'ik dĕr'mă-tō'sis)
A pruritic papular eruption of the chest, with scattered lesions of the back and lateral aspects of the limbs, lasting from weeks to months; seen predominantly in men older than 40 years of age.
Synonym(s): Grover disease.

Grover disease

[R. W. Grover, contemporary U.S. dermatologist]
A common itchy (pruritic) condition of sudden onset, characterized by a few or numerous smooth or warty papules, vesicles, eczematous plaques, or shiny translucent nodules. The pruritus may be mild or severe and is aggravated by heat. Even though the condition is self-limiting, it may last months or years.


The patient should be treated symptomatically. Heat and sweat-inducing activities should be avoided. Retinoic acid may be helpful.


Ralph W., U.S. dermatologist, 1920–.
Grover disease - a pruritic papular eruption. Synonym(s): transient acantholytic dermatosis
References in periodicals archive ?
The histologic differential diagnosis includes other vesiculo-bullous disorders, such as acantholytic actinic keratosis, acantholytic squamous cell carcinoma, Grover disease, and pemphigus vulgaris, among others.
A retrospective cohort study in 185 patients with unresectable stage IIIC and IV melanoma showed those treated with BRAF inhibitors dabrafenib or vemurafenib in combination with a MEK inhibitor had zero cases of cutaneous squamous cell carcinoma, verrucal keratosis, or Grover disease but a 40% incidence of folliculitis, according to a paper published online July 22 in JAMA Dermatology.
In contrast, the rates of cutaneous squamous cell carcinoma were significantly higher among patients treated with either dabrafenib or vemurafenib alone (26% and 36%, respectively), as was the incidence of Grover disease (43% and 39%) and verrucal keratosis (66% and 72%).
Acantholytic disorders of the skin: Darier-White disease, acrokeratosis verruciformis, grover disease, and Hailey-Hailey disease," in Fitzpatrick's Dermatology in General Medicine, 7e, K.
Piebaldism may be associated with other disorders such as Hirschsprung disease, neurofibromatosis type I, congenital dyserythropoietic anemia type II, Diamond-Blackfan anemia, Grover disease, or transient acantholytic disease [3].
1) Although the diagnostic terms Grover disease and transient acantholytic dermatosis can be used interchangeably, here we will use the more clinical conventional and widely recognizable term Grover disease.
After the original description of Grover disease, Grover and Rosenbaum (2) discovered a clinically significant association between Grover disease and other dermatitites.
The prototypic presentation of Grover disease consists of a self-limited papulovesicular rash on the upper trunk of an older white male (Figure 1).
The seasonal association of Grover disease is more controversial.
Grover disease has been found to coexist with numerous other dermatoses in 11% of cases (5); these include asteatotic eczema, allergic contact dermatitis, atopic dermatitis, irritant contact dermatitis, and psoriasis.
Histologically, the acantholysis seen in Grover disease occurs in a variety of different patterns in small, circumscribed foci resembling Darier-White disease, pemphigus vulgaris, pemphigus foliaceous, Hailey-Hailey disease, and a spongiotic dermatitis.
Eosinophils have been identified in nearly one quarter of biopsies of Grover disease, (5) which has been found by some authors to be useful in distinguishing between predominant Darier-like pattern of Grover disease and Darier disease, in which they are usually absent.