HSPD1

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HSPD1

A gene on chromosome 2q33.1 that encodes a mitochondrial protein of the chaperonin family, which may function as a signalling molecule in the innate immune system. It is essential for the folding and assembly of newly imported proteins in mitochondria. HSPD1 is adjacent to a related gene; the region between the two acts as a bidirectional promoter.

Molecular pathology
HSPD1 mutations cause autosomal recessive spastic paraplegia 13.
References in periodicals archive ?
Aiming to search for accurate methods to identify strains showing atypical results in the coagulation assays, we estimated the identification potential of four different techniques: Matrix-Assisted Laser Desorption Ionization-Times of Flight Mass Spectometry (MALDI-TOF), PCR-restriction fragment length polymorphism (PCR-RFLP) of the chaperonine gene groEL, and DNA sequencing of the 16S rRNA and elongation factor Tu gene tuf
DNA'lardan L.acidophilus ve L.casei miktarlarinin saptanmasi icin tablo 1'deki Hsp60, groEL bolgesi spesifik primer ve problar kullanilarak LightCycler 480 II (Roche Diagnostics, Mannheim, Almanya) real-time PCR sisteminde, Fast Start Essential Probe Master Mix kiti (Roche Diagnostics GmBH, Mannheim Almanya) ile her bir reaksiyona tablo 2'deki reaktif miktarlari yuklenerek uretici direktifleri dogrultusunda calisma yapildi (11, 12).
This increased thermal tolerance is partially due to the activation of conserved heat shock proteins (Hsps) (e.g., DnaK and GroEL) under sublethal heat temperatures (Doyle et al., 2001; Ferreira et al., 2001; Hill et al., 2002).
We confirmed EMLA positivity of the samples by amplifying and sequencing the EMLA citrate synthase (gltA) and heat shock protein (groEL) genes (3).
A highly sensitive quantitative real-time PCR assay based on the groEL gene of contemporary Thai strains of Orientia tsutsugamushi.
The synthesis of DnaK and GroEL was induced during infection, evidenced by antibodies detected in sera from patients with S.
CpaB, CpaF/TadA, TadB, pilQ/Cpac, pilV, flp1, flp2 (genes associated with type IV pilus secretion), chemotaxis protein (MCP: methyl accepting chemotaxis protein, chemotaxis protein CheY), heat-shock protein (GroES and GroEL), cell wall-associated protein (wapA), host interaction (hit) locus orf.
Identification of Salmonella isolated from poultry by MPCR technique and evaluation of their hsp groEL gene diversity based on the PCR-RFLP analysis.