Kinetics of the Grignard reaction
with silanes in diethyl ether and ether-toluene mixtures.
Noteworthy are (a) the unusual structural features of ND354, (b) the use of a Grignard reaction
of a lactam in its synthesis; (c) cholesterol inhibition by action at the lanosterol stage without a build up of sterol precursors and (d) absence of adverse side effects in animal or human studies.
We synthesized Tris-OH by adding 4-chlorobromobenzene to 4,4'-dichlorobenzophenone by a Grignard reaction
. In a reactor under a nitrogen atmosphere, we added 1.34 g magnesium to 15 mL dry diethyl ether.
This broadens the already existing expertise and infrastructure in nitration reactions, oxidations, Grignard reaction
and azide chemistry.
The previously discussed advantages of continuous flow can certainly be utilized to improve the performance of lithiations, but another alternative is replacement by Grignard reactions
to avoid the problems of maintaining low temperatures.