Grignard reaction


Also found in: Dictionary, Encyclopedia, Wikipedia.

Grignard reaction

(grē-nyar′) [François AugusteVictor Grignard, French chemist and Nobel laureate, 1871–1935]
A classical organic-chemical process that forms carbon-carbon bonds. It is used to build carbon chains in compounds including drugs, food additives, toxins, and pesticides.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Noteworthy are (a) the unusual structural features of ND354, (b) the use of a Grignard reaction of a lactam in its synthesis; (c) cholesterol inhibition by action at the lanosterol stage without a build up of sterol precursors and (d) absence of adverse side effects in animal or human studies.
We synthesized Tris-OH by adding 4-chlorobromobenzene to 4,4'-dichlorobenzophenone by a Grignard reaction. In a reactor under a nitrogen atmosphere, we added 1.34 g magnesium to 15 mL dry diethyl ether.
This broadens the already existing expertise and infrastructure in nitration reactions, oxidations, Grignard reaction and azide chemistry.
The previously discussed advantages of continuous flow can certainly be utilized to improve the performance of lithiations, but another alternative is replacement by Grignard reactions to avoid the problems of maintaining low temperatures.