Graves disease


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia, Wikipedia.
Related to Graves disease: hypothyroidism, Hashimoto's disease

Graves dis·ease

(grāvz), [MIM*275000] Avoid the incorrect forms Grave and Grave's.
1. toxic goiter characterized by diffuse hyperplasia of the thyroid gland, a form of hyperthyroidism; exophthalmos is a common, but not invariable, concomitant finding;
2. thyroid dysfunction and all or any of its clinical associations;
3. an organ-specific autoimmune disease of the thyroid gland.

Graves dis·ease

(grāvz di-zēz')
1. Toxic goiter characterized by diffuse hyperplasia of the thyroid gland, a form of hyperthyroidism; exophthalmos is a common, but not invariable, concomitant finding.
2. Thyroid dysfunction and all or any of its clinical associations.
3. An organ-specific autoimmune disease of the thyroid gland.
See: thyrotoxicosis, Hashimoto disease, goiter, myxedema
Synonym(s): Parry disease.

Graves,

Robert James, Irish physician, 1796-1853.
Graves disease - thyroid dysfunction and all or any of its clinical associations. Synonym(s): Basedow disease; Marsh disease; ophthalmic hyperthyroidism; Parry disease
Graves ophthalmopathy - exophthalmos associated with thyroid disease. Synonym(s): endocrine ophthalmopathy; Graves orbitopathy
Graves orbitopathy - Synonym(s): Graves ophthalmopathy

Marsh,

Sir Henry, Irish physician, 1790-1860.
Marsh disease - Synonym(s): Graves disease

Graves dis·ease

(grāvz di-zēz') [MIM*275000]
1. Toxic goiter characterized by diffuse hyperplasia of the thyroid gland, a form of hyperthyroidism.
2. Thyroid dysfunction and all or any of its clinical associations.
3. Organ-specific autoimmune disease of thyroid gland.
Synonym(s): Basedow disease.
References in periodicals archive ?
The mean size of the tumor in the patients with AFTN was significantly larger than it was in those with Graves disease (42.
Thyroid autoantibody profiles in ophthalmic dominant and thyroid dominant Graves disease differ and suggest ophthalmopathy is a multiantigenic disease.
Such occurrences should not be a problem, however, because patients with Graves disease with hyperthyroidism should have TSH concentrations below the reference interval (<0.
An unusual cause of anterior mediastinal mass: thymic hyperplasia resulting from Graves disease.
The patient's serum thyrotropin immunoglobulin level was slightly elevated at 220 mg/dl (normal, <130 mg/dl), confirming Graves disease.
Clearly, our current data suggest that modern binding-based assays rival bioassays in sensitivity in the sera from patients with Graves disease.
The study involved 153 patients (125 women and 28 men; median age, 42 years; range, 17-65 years) with Graves disease diagnosed from typical clinical signs: hyperthyroidism, vascular and homogeneous goiter, occasional exophthalmos, increased free thyroid hormone concentrations (free triiodothyronine >8.
Diagnosis of Graves disease can be difficult because healthy pregnant women may exhibit tachycardia, palpitations, mild heat intolerance, emotional lability, diaphoresis, and warm, moist skin.
Hyperthyroidism in Graves disease is attributable to autoantibodies to the thyroid-stimulating hormone receptor (TSHR), and measurement of these TSHR autoantibodies (TRAbs) can be useful in disease diagnosis and management (1-4).
Autoantibodies to the thyrotropin (TSH) receptor (TSHR) are the hallmark of the autoimmune response to the thyroid gland and are responsible for thyrotoxicosis in Graves disease (1).