Graves disease


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Related to Graves disease: hypothyroidism, Hashimoto's disease

Graves dis·ease

(grāvz), [MIM*275000] Avoid the incorrect forms Grave and Grave's.
1. toxic goiter characterized by diffuse hyperplasia of the thyroid gland, a form of hyperthyroidism; exophthalmos is a common, but not invariable, concomitant finding;
2. thyroid dysfunction and all or any of its clinical associations;
3. an organ-specific autoimmune disease of the thyroid gland.

Graves dis·ease

(grāvz di-zēz')
1. Toxic goiter characterized by diffuse hyperplasia of the thyroid gland, a form of hyperthyroidism; exophthalmos is a common, but not invariable, concomitant finding.
2. Thyroid dysfunction and all or any of its clinical associations.
3. An organ-specific autoimmune disease of the thyroid gland.
See: thyrotoxicosis, Hashimoto disease, goiter, myxedema
Synonym(s): Parry disease.

Graves,

Robert James, Irish physician, 1796-1853.
Graves disease - thyroid dysfunction and all or any of its clinical associations. Synonym(s): Basedow disease; Marsh disease; ophthalmic hyperthyroidism; Parry disease
Graves ophthalmopathy - exophthalmos associated with thyroid disease. Synonym(s): endocrine ophthalmopathy; Graves orbitopathy
Graves orbitopathy - Synonym(s): Graves ophthalmopathy

Marsh,

Sir Henry, Irish physician, 1790-1860.
Marsh disease - Synonym(s): Graves disease

Graves dis·ease

(grāvz di-zēz') [MIM*275000]
1. Toxic goiter characterized by diffuse hyperplasia of the thyroid gland, a form of hyperthyroidism.
2. Thyroid dysfunction and all or any of its clinical associations.
3. Organ-specific autoimmune disease of thyroid gland.
Synonym(s): Basedow disease.
References in periodicals archive ?
Four patients (50%) had AFTN that contained the carcinoma, 3 were diagnosed with Graves disease, and 1 (13%) had a toxic multinodular goiter.
The mean size of the tumor in the patients with AFTN was significantly larger than it was in those with Graves disease (42.3 [+ or -] 23.8 mm vs.
The combination of absent thyroid peroxidase antibodies and high thyroid-stimulating immunoglobulin levels in Graves disease identifies a group at markedly increased risk of ophthalmopathy.
Effect of high dose methylprednisolone pulse therapy followed by oral prednisolone administration on the production of anti-TSH receptor antibodies and clinical outcome in Graves disease. Endocr J 2005;52:735-41.
Results for 5 of 6 Graves patient samples provided by Kronus from patients clinically diagnosed with Graves disease were positive (TSH concentrations 370%, 382%, 371%, 262%, and 316%) and 1 was indeterminate (115% of the reference interval TSI value).
Radiotherapy-induced ophthalmopathy associated with Graves disease most likely results from an autoimmune reaction secondary to a thyroid injury caused by the radiation.
Clearly, our current data suggest that modern binding-based assays rival bioassays in sensitivity in the sera from patients with Graves disease. Discrepancies may be seen more often in patients with primary hypothyroidism who may be more likely to have inhibitory antibodies that are not seen in the stimulatory bioassay.
The study involved 153 patients (125 women and 28 men; median age, 42 years; range, 17-65 years) with Graves disease diagnosed from typical clinical signs: hyperthyroidism, vascular and homogeneous goiter, occasional exophthalmos, increased free thyroid hormone concentrations (free triiodothyronine >8.9 pmol/L and free thyroxine >23.4 pmol/L), and undetectable TSH (<0.05 mIU/ L).
Thyroid anti-microsomal antibodies (also known as thyroid peroxidase antibodies or TPO antibodies) are increased in most (80-90%) patients with Graves disease, and thyroid hormone receptor antibodies (TRAbs) are increased in ~80% or more of patients (25, 28).
We compared the ELISA and the conventional TRAb receptor assay based on [sup.125]I-labeled TSH and PEG precipitation (5) in 56 sera from patients suspected of having Graves disease (Fig.
In samples from 24 untreated patients with Graves disease and positive TBII (group A in Fig.
Two samples from patients with autoimmune thyroid disorders (Graves disease and postpartum thyroiditis) contained only anti-bovine TSH antibodies.