About Graves' Orbitopathy Graves' Orbitopathy
is an autoimmune inflammatory disorder affecting the orbit around the eye, characterized by upper eyelid retraction, lid lag, swelling (edema), redness (erythema), conjunctivitis, and bulging eyes (proptosis).
Moderately severe and active forms of Graves' orbitopathy can be effectively treated with glucocorticoids, orbital irradiation, or both.
One hundred fifty-nine patients with mild Graves' orbitopathy were randomly assigned to receive, in double-blind fashion, selenium (an antioxidant) at a dose of 100 mcg twice a day, pentoxifylline (an anti inflammatory agent) at a dose of 600 mg twice a day, or placebo for 6 months, and were then followed for an additional 6 months.
Claudio Marcocci of the department of endocrinology and metabolism at the University of Pisa (Italy) and his associates in the European Group on Graves' Orbitopathy.
Selenium (an antioxidant) and pentoxifylline (an anti-inflammatory) were chosen as potentially therapeutic agents to test in this trial because in vitro and small pilot studies have suggested that they might be beneficial in Graves' orbitopathy.
Other endoscopic procedures replacing the more conventional open procedures include endoscopic dacryocystorhinostomy (DCR) for epiphora (watery eye due to nasolacrimal duct obstruction), orbital decompression for Graves' orbitopathy
, optic nerve decompression, drainage of fronto-ethmoidal mucoceles and external fronto-ethmoidectomies for persistent frontal sinus disease.
He is an active member of EUGOGO, the European Group on Graves' Orbitopathy
Sinusitis-related orbital infection is the most common cause of unilateral proptosis in children and the third leading cause in adults, behind Graves' orbitopathy
Thyritope Biosciences is developing therapeutics that target thyroid stimulating auto-antibodies, which are the causative drivers of Graves' hyperthyroidism and Graves' orbitopathy
PARIS -- Rituximab seemed to be safe and effective for six patients with severe Graves' orbitopathy that was refractory to steroid therapy, Dr.
Rituximab is used in treating rheumatoid arthritis and has recently been examined for possible benefit in other autoimmune disorders, including Graves' orbitopathy.
Wiersinga (endocrinology and metabolism, Academic Medical Center, University of Amsterdam, The Netherlands) and Kahaly (medicine, Gutenberg University Hospital) assemble members of the European Group on Graves' Orbitopathy
(EUGOGO) to present the current understanding of the thyroid eye disease Graves' orbitopathy