Immunovant, a biopharmaceutical company focused on developing innovative therapies for patients living with debilitating autoimmune diseases and currently evaluating IMVT-1401 in patients with moderate-to-severe active Graves' ophthalmopathy
(GO), announced yesterday that it has named Pete Salzmann, MD as its new chief executive officer.
Immunovant recently announced the start of dosing in ASCEND-GO 1, an open label, single-arm Phase 2a clinical trial evaluating IMVT-1401 in patients with moderate-to-severe active Graves' ophthalmopathy
is an inflammatory disease of the eye and orbital tissues, and its prevalence has been previously reported to range from 17.1-67.6% in children and adolescents with GD (21,27).
Visual evoked potentials in patients with Graves' ophthalmopathy
complicated by ocular hypertension and suspect glaucoma or dysthyroid optic neuropathy.
In adults, it is commonly related to Graves' ophthalmopathy
, orbital pseudotumor, and rhinosinusitis-related orbital infections.
Multiple sclerosis, Graves' ophthalmopathy
, Miller-Fisher syndrome, mitochondrial diseases, oculopharyngeal muscular dystrophy, vascular causes, and tumors were considered in the differential diagnosis.
Our results were in agreement with Vestergaard20 as he reported that GD patients who smoke had a 5 times higher threat of developing Graves' ophthalmopathy
than those who do not smoke.
is a potentially sight-threatening disease of the orbital cavity, generally accompanied by hyperthyroidism associated with Graves' disease .
Thyroid-associated orbitopathy (TAO), also known as thyroid eye disease or Graves' ophthalmopathy
, is an autoimmune disease affecting the thyroid, orbits, and skin.
," New England Journal of Medicine, vol.
Tanda et al., "Comparison of the effectiveness and tolerability of intravenous or oral glucocorticoids associated with orbital radiotherapy in the management of severe Graves' ophthalmopathy
: results of a prospective, single-blind, randomized study," The Journal of Clinical Endocrinology & Metabolism, vol.
Esser, "Surgical treatment of Graves' ophthalmopathy
," Best Practice and Research Clinical Endocrinology and Metabolism, vol.