Grapefruit Juice Effect

The effect that grapefruit juice has on the body, in particular, by increasing the effects of some drugs, due to the bergamottin in grapefruit juice, which blocks cytochrome P-450 CYP3A4 and CYP1A2, which in turn increases the serum levels of those drugs metabolised by those cytochrome P-450 pathways serum levels of certain drugs
References in periodicals archive ?
Bergamottin is "an important lead, but the jury is still out" on whether it causes the grapefruit juice effect, says David G.
Bailey and his colleagues first stumbled across the grapefruit juice effect in 1989, while studying how alcohol interacts with a drug called felodipine, used to treat high blood pressure.
The ultimate proof will come from human tests of bergamottin to see if it can reproduce the grapefruit juice effect, says Bailey.