com)-- H2Biologics announced that it has been granted a worldwide, exclusive license by the Research Development Foundation (RDF) for the use of human granzyme B (GrB), a naturally occurring serine protease, in developing an immunoconjugate with a human single domain antibody (SD1) that targets mesothelin-expressing tumors.
This group has generated a number of targeted anticancer therapeutic proteins using granzyme B as the payload and demonstrated potent anti-tumor killing in preclinical studies.
Researchers found that a three-month course of azithromycin suppressed production of granzyme B
, considered "a natural born killer" cell, in the airway epithelium (Respirology, October 2014).
Prostate cancer cells contain low levels of proteins perforin and granzyme B
, which can work together to kill cells.
Prostate tumour cells contain very low levels of two proteins, perforin and granzyme B
, which can function together to kill cells.
Granville and his team identified a protein-degrading enzyme called Granzyme B
that is abundant in aneurysms.
Example apoptosis-inducing genes include caspase 3, caspase 4, caspase 5, Granzyme B
In their study, levels of messenger RNA (mRNA) encoding perforin and granzyme B
, 2 proteins produced by cytotoxic cells, were measured in the urine of 85 renal allograft recipients with or without an episode of acute rejection.