granzyme

(redirected from Granzyme B)

granzyme

(grăn′zīm)
Any of a family of proteases stored in the granules of cytotoxic T lymphocytes. They are involved in cytolytic functions.
References in periodicals archive ?
com)-- H2Biologics announced that it has been granted a worldwide, exclusive license by the Research Development Foundation (RDF) for the use of human granzyme B (GrB), a naturally occurring serine protease, in developing an immunoconjugate with a human single domain antibody (SD1) that targets mesothelin-expressing tumors.
This group has generated a number of targeted anticancer therapeutic proteins using granzyme B as the payload and demonstrated potent anti-tumor killing in preclinical studies.
Researchers found that a three-month course of azithromycin suppressed production of granzyme B, considered "a natural born killer" cell, in the airway epithelium (Respirology, October 2014).
Prostate cancer cells contain low levels of proteins perforin and granzyme B, which can work together to kill cells.
Prostate tumour cells contain very low levels of two proteins, perforin and granzyme B, which can function together to kill cells.
Granville and his team identified a protein-degrading enzyme called Granzyme B that is abundant in aneurysms.
Example apoptosis-inducing genes include caspase 3, caspase 4, caspase 5, Granzyme B.
In their study, levels of messenger RNA (mRNA) encoding perforin and granzyme B, 2 proteins produced by cytotoxic cells, were measured in the urine of 85 renal allograft recipients with or without an episode of acute rejection.