graft versus host disease


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graft ver·sus host dis·ease (GVHD),

an incompatibility reaction (that may be fatal) in a subject (host) of low immunologic competence who has been the recipient of immunologically competent lymphoid tissue from a donor who is immunologically different from the recipient; the reaction, or disease, is the result of action of the transplanted cells against those host tissues that possess an antigen not found in the donor. Seen most commonly following bone marrow transplantation, acute disease is seen after 7-30 days and chronic disease weeks to months after transplantation, affecting, principally, the gastrointestinal tract, liver, and skin.
Synonym(s): GVH disease

Graft versus host disease

A life-threatening complication of bone marrow transplants in which the donated marrow causes an immune reaction against the recipient's body.
References in periodicals archive ?
The report reviews pipeline therapeutics for Graft Versus Host Disease (GVHD) by companies and universities/research institutes based on information derived from company and industry-specific sources
A review of the Graft Versus Host Disease (GVHD) products under development by companies and universities/research institutes based on information derived from company and industry-specific sources
Acute graft versus host disease after liver transplantation: patterns of lymphocyte chimerism.
Graft versus Host Disease (GvHD) is one of the potentially fatal complications of hematopoietic stem cell transplantation (HCT).