Good syndrome (thymoma with immunodeficiency) is a rare cause of immunodeficiency.
Given his leukopenia and failure to improve the suspicion of Good syndrome was raised and serum immunoglobulins levels were checked and found to be low with a reversal of the patients CD4/CD8ratio (Table-1).
Based on these findings he was treated with intravenous immunoglobulin's for Good syndrome during his stay in ICU.
Good syndrome (immunodeficiency with concomitant thymoma) is a rare cause of combined B- and T-cell immunodeficiency in adults.
Patients with Good syndrome usually present in the 4th or 5th decade of life, and the frequency in males and females is similar.
4 Aspergillus is a rare cause complicating Good syndrome and a recent review of 152 Good syndrome cases revealed only 4 cases of aspergillus infections.
2 The treatment of patients with Good syndrome includes resection of the thymoma and immunoglobulin replacement to maintain adequate IgG levels.
As high mortality is associated with this condition it is imperative that clinicians should have a high index of suspicion for diagnosing Good syndrome in patients with thymoma so that immunoglobulin therapy can be initiated.