GnRH antagonists

A group of medications that affect the reproductive hormones. These medications are used to treat fibroids, endometriosis, and infertility.

Mentioned in: Uterine Fibroids

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References in periodicals archive ?

On the other hand, GnRH antagonists bind to GnRH receptors with high affinity.

Effect of GNRH antagonists on clinical pregnancy rates in controlled ovarian stimulation and intrauterine insemination

In the antagonist protocol, FSH analogues were started at the beginning of the follicular phase of the cycle, and GnRH antagonists were added when the leading follicles reached 12-13 mm in diameter.

Outcome of intracytoplasmic sperm injection after preinstillation of a gonadotropin releasing hormone agonist in the uterine cavity just before embryo transfer/Embriyo transferi oncesi uterin kaviteye gonadotropin serbestlestirici hormon agonisti enjeksiyonunun intrasitoplazmik sperm enjeksiyonu sonuclari

Although none of medical strategies is completely effective, there is high-quality evidence that replacing human chorionic gonadotropin (hCG) by gonadotropin-releasing hormone (GnRH) agonists after GnRH antagonists and moderate-quality evidence that GnRH antagonist protocols, dopamine agonists and mild protocols reduce the occurrence of OHSS.

Current medical strategies in the prevention of ovarian hyperstimulation syndrome

In recent years, GnRH antagonists (GnRH-ant) have been used in the treatment of POR to prevent the LH surge.

Microdose flare-up gonadotropin-releasing hormone (GnRH) agonist versus GnRH antagonist protocols in poor ovarian responders undergoing intracytoplasmic sperm injection

Anti-androgens and GnRH antagonists are usually prescribed for long term which is also expected to surge the market of hormone sensitive prostate cancer.

Now Available: Global Hormone Sensitive Prostate Cancer Market Forecast and Growth 2016-2026

The exact impact of these protocols has been controversial following early reports that GnRH antagonists were associated with lower pregnancy rates.

GnRH-antagonist protocol trims severe OHSS

Men on ADT with GnRH agonists have incomplete reduction of serum FSH levels compared to GnRH antagonists, which lead to a more immediate and sustained decrease.

Serum follicle-stimulating hormone levels predict time to development of castration-resistant prostate cancer

There is a controversial discussion about the better regimen choice15 and clinical advantages of GnRH antagonists over agonists.

Prediction of success in intracytoplasmic sperm injection (ICSI) by estimation of serum Estradiol/Progesterone ratio on the day of embryo transfer

They suggest that GnRH antagonists are an attractive option for ovulation induction in women with PCOS.

In this issue

Under the collaboration agreement Abbott will be granted the worldwide exclusive rights to develop and commercialise elagolix and all next-generation GnRH antagonists for women's and men's health.

Abbott and Neurocrine partner to commercialise elagolix for endometriosis-related pain

Frequently, treatment of hormone-responsive cancers involves GnRH antagonists or very, very high doses of GnRH, which cause side effects," said George Bentley, UC Berkeley assistant professor of integrative biology.

Reproduction-suppressing hormone may offer new contraceptives, cancer cure

These drugs include the aromatase inhibitors, mefipristone, selective oestrogen-receptor modulators, selective progesterone-receptor modulators, GnRH antagonists, pentoxyfylline and drugs that inhibit the effects of tumour necrosis factor, [alpha]-matrix metalloproteinase, and angiogenesis.