GnRH antagonists

GnRH antagonists

A group of medications that affect the reproductive hormones. These medications are used to treat fibroids, endometriosis, and infertility.
Mentioned in: Uterine Fibroids
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Jehonathan Pinthus and colleagues presented research in animal models, suggesting possible differences between surgical castration, a GnRH antagonist (degarelix) and a GnRH analogue (enantone) with respect to weight gain, development of the metabolic syndrome, and atherosclerosis.[sup.3] The hypothesis was that GnRH antagonists, which maximally inhibit follicle-stimulating hormone (FSH) levels, would be associated with reduced adiposity, the development of metabolic syndrome and CV disease compared to GnRH analogues and orchiectomy.
New trends in androgen deprivation therapy: Summary of key research presented at AUA 2014
The introduction of newer GnRH analogues, the GnRH antagonists, created the potential for milder stimulation protocols that are better tolerated and less costly, have a quicker onset of action, result in a lower incidence of luteinising hormone (LH) surge, and are associated with a lower multiple pregnancy rate.
Is the use of a GnRH antagonist effective in patients with polycystic ovarian syndrome? A South African perspective
Klotz said: "More than 2,000 patients have now taken part in clinical trials for degarelix and there have been no signs of immediate or late-onset systemic allergic reactions, in contrast to other reported trials of other GnRH antagonists.
Prostate cancer drug reduces testosterone levels within 3 days
Lamvu said she is most optimistic about the potential for new GnRH antagonists to make a significant improvement in chronic pelvic pain associated with endometriosis.
Histology necessary to confirm diagnosis of endometriosis
In the antagonist protocol, FSH analogues were started at the beginning of the follicular phase of the cycle, and GnRH antagonists were added when the leading follicles reached 12-13 mm in diameter.
Outcome of intracytoplasmic sperm injection after preinstillation of a gonadotropin releasing hormone agonist in the uterine cavity just before embryo transfer/Embriyo transferi oncesi uterin kaviteye gonadotropin serbestlestirici hormon agonisti enjeksiyonunun intrasitoplazmik sperm enjeksiyonu sonuclari
Refinement in GnRH antagonists continued after 1984, initially hampered by histamine release side-effects, which were overcome in 1994 with the third-generation GnRH antagonists that are currently in clinical use but still under assessment with regard to efficacy.
A brief historical overview of assisted reproduction
Another advance involves GnRH antagonists for controlled ovarian hyperstimulation for IVF.
Latest IVF protocols prove more user friendly. (Fewer Shots, side Effects)
GnRH antagonists have a relatively weaker binding affinity to GnRH receptors than that of GnRH agonists.
Effect of pre-ovulatory single dose GnRH agonist therapy on IVF outcome in GnRH antagonist cycles; a prospective study
New forms of GnRH antagonists under development are likely to be far more effective, he said.
Desire for fertility should guide endometriosis Tx. (Expert Opinion)
reported stimulation of poor responders by a combination of gonadotropins, clomiphene citrate, and multiple flexible GnRH antagonists (29).
Strategies for pituitary down-regulation to optimize IVF/ICSI outcome in poor ovarian responders
Comparison of preovulatory follicular concentrations of epidermal growth factor, insulin-like growth factor-I, and inhibins A and B in women undergoing assisted conception treatment with gonadotropin-releasing hormone (GnRH) agonists and GnRH antagonists. Fertil Steril.
Prediction and diagnosis of poor ovarian response: the dilemma
Although use of GnRH antagonists in some controlled clinical trials showed that the frequency of the severe form of OHSS is lower than in case when agonists are used, one cannot exclude a probability that such results are a consequence of possibility that agonists are often used instead of hCG in protocols with antagonists as ovulation triggers, which may itself reduce incidence of OHSS.21 However, patient's predisposition for developing OHSS is still considered as the most probable factor which is also in line with our results.
Risk of spontaneous preterm labor in pregnancies achieved by in vitro fertilization and complicated with severe form of ovarian hyperstimulation syndrome: A case control study

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