gonadotropin-releasing hormone analogue

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gonadotropin-releasing hormone analogue

A polypeptide analogue of gonadotropin-releasing hormone–GnRH; some are more potent than GnRH in stimulating gonadotropin release Examples Leuprolide, histrelin, administered in a pulsatile fashion to restore lost GnRH, normalize pituitary-gonadal function, as in congenital GnRH deficiencies–eg, hypogonadotropic hypogonadism with Kallmann syndrome or without anosmia, or in acquired GnRH deficiency secondary to RT of the CNS, pituitary tumors, or panhypopituitarism. See Gonadotropin-releasing hormone.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Combined therapy with GnRH analog plus growth hormone in central precocious puberty.
Twenty-four-hour pattern of growth hormone (GH) concentration in the plasma of rats administered placebo, dalarelin and cetrorelix for: a) 2 months of GnRG analog administration, b) 3 months of GnRH analog administration, c) 1 week after treatment discontinuation, d) 2 weeks after treatment discontinuation
The objective of the study was to evaluate the clinical efficacy and safety of domestic leuprorelin (GnRH analog) in girls with ICPP.
GnRH analog works by competing occupied GnRH receptors, causing suppression of the gonads and amenorrhea in patients.
Twenty percent of hypothalamic GnRH-I secreting neurons possess CBj, and buserelin, a long acting GnRH analog, increases [CB.sub.1] expression and inhibits those of GnRH-I [88].
Uncertainties about the benefits of GnRH analog treatment on growth of children with CPP comes from the fact that there is no randomised controlled study on this respect.
[sup][14] However, this cut-off value is a little higher than other GnRH analog stimulation tests, such as buserelin, nafarelin, leuprolide, and triptorelin.
Diamond therefore recommends prior treatment of late-stage endometriosis with GnRH analog and possibly surgery when there is hope of reducing endometriomas, improving the environment for ART, and reducing toxicity associated with extensive endometriosis.