Holmes, "Glycolate and glyoxylate
metabolism in HepG2 cells," American Journal of Physiology: Cell Physiology, vol.
"We didn't know what to expect but the glyoxylate
scenario with respect to formation of carbohydrates is not a hypothesis anymore, it's an experimental fact."
DCA is dehalogenated to glyoxylate
by the cytosolic zeta-1 family isoform of glutathione transferase (GSTzl), which is identical to maleylacetoacetate isomerase (MAAI), the penultimate enzyme in the phenylalanine/tyrosine catabolic pathway [see Supplemental Material, Figure 2 (doi:10.1289/ehp.1002554)].
This mixture catalyzes the glyoxylate
ene reaction to give higher enantioselectivities, higher yields and a more general catalyst.
MLS and ICL are key enzymes of the glyoxylate
cycle required for fungal virulence .
Acetaldehyde can then be converted to ethanol or, more likely, into acetyl-CoA, which can be used in numerous cell processes (Krebs cycle, glyoxylate
bypass, lipid biosynthesis, or other processes) .
Functional synergism between the most common polymorphism in human alanine: glyoxylate
aminotransferase and four of the most common disease-causing mutations.
regeneration pathway in the methylotroph Methylobacterium extorquens AM1," Journal of Bacteriology, vol.
Cra was found to play as an activator of most of the genes encoding enzymes for gluconeo genesis, TCA cycle, and glyoxylate
shunt pathway, and as a repressor of the genes encoding EntnerDoudoroff pathway and glycolysis (Fig.
The acetyl-CoA is metabolized through the TCA cycle and the glyoxylate
shunt pathway by isocitrate lyase (aceA) and malate synthetase (aceB).
The production of formate, a substrate for methanogenesis, from compounds related with the glyoxylate
cycle by mixed ruminal microbes.
Primary hyperoxaluria type 1 (PH1)  (OMIM 259900) is an autosomal recessive disorder of glyoxylate
metabolism caused by deficiency of alanine:glyoxylate aminotransferase (AGT; EC 22.214.171.124).