glycosylphosphatidylinositol


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glycosylphosphatidylinositol

(glī″kō-sĭl-fŏs′fă-tī-dĭl-ĭn-ŏs′ĭ-tŏl″),

GPI

A lipid in the plasma membrane of cells that anchors proteins on the cell's surface. Some of the proteins held on the cell surface protect cells against attack by serum complement. Mutations that decrease or eliminate GPI are responsible for the destruction of blood cells by the complement system, which characterizes the disease called paroxysmal nocturnal hemoglobinuria.
References in periodicals archive ?
1991) Identification of defects in glycosylphosphatidylinositol anchor biosynthesis in the Thy-1 expression mutants.
The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins.
Neutralizing monoclonal antibodies to glycosylphosphatidylinositol, the dominant TNF-alpha-inducing toxin of Plasmodium falciparum: prospects for the immunotherapy of severe malaria.
ubiquitum gp60 gene sequence had a C-terminus hydrophobic region that is likely linked to a glycosylphosphatidylinositol anchor, 2 potential N-linked glycosylation sites, and numerous O-linked glycosylation sites (26,27).
The glycosylphosphatidylinositol (GPI) anchor of malarial membrane proteins may cause cellular dysfunction, but a role for this toxin in dyserythropoiesis remains to be established (26).
In addition, the former are characterized by a C-terminal tail that predicts the incorporation of a glycosylphosphatidylinositol group (GPI) that allows the attachment of the AGPs to the plasma membrane.
In contrast to most existing vaccines, the new vaccine targets not proteins on the pathogen's exterior but rather a compound called glycosylphosphatidylinositol (GPI) that seems to cause malaria's most deadly symptoms--and may be a long-sought malaria toxin.
These chambers were rich in proteins that use a specific chemical anchor (called glycosylphosphatidylinositol or GPI) to stick to the cell membrane, the Dallas researchers note.
Special emphasis is placed on glycosylphosphatidylinositol (GPI) anchoring, ABC phospholipid translocators, elongation factor-2 and calcineurin.
Membrane type MMPs (MT-MMP) (MMP-14, MMP-15, MMP-16, MMP-17, MMP24, and MMP-25) are anchored to the plasma membrane by a transmembrane domain with a cytoplasmic domain or a glycosylphosphatidylinositol (GPI).
44) Studies have shown that glycosylphosphatidylinositol (GPI), a malarial toxin, binds to the pattern recognition receptors of the innate immune system and stimulates pro-inflammatory cytokine production.
A glycosylphosphatidylinositol anchor signal sequence enhances the immunogenicity of a DNA vaccine encoding Plasmodium falciparum sexualstage antigen, Pfs230.

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