glycosylated haemoglobin

glycosylated haemoglobin

A normal chemical linkage between haemoglobin and glucose. The amount of glucose linked in this way is proportional to the average levels of glucose in the blood. This provides an independent check of the quality of blood sugar control in DIABETES and is a useful monitoring aid.
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The primary outcome of the trial was a change from baseline in glycosylated haemoglobin (HbA1c) for Saroglitazar 4 mg, 2 mg and Pioglitazone 30 mg at 24 weeks.
Glycosylated haemoglobin (HbA1c) values were significantly higher in non-diabetic IDA patients implying that iron deficiency anaemia leads to a rise in the glycosylated haemoglobin values.
Blood was centrifuged for blood sugar, glycosylated haemoglobin, total cholesterol, high-density lipoprotein, low-density lipoprotein, triglyceride and asymmetrical dimethylarginine.
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Haemoglobin and glycosylated haemoglobin were analyzed with automated haematology analyzer Sysmex K-1000, which is a fully automated qualitative haematology analyzer for in-vitro diagnostic use in clinical laboratories.
"The diabetes screening tests that were available in the gazebo this year included the Glycosylated Haemoglobin level test, which is a test that shows the average level of blood sugar (glucose) over the previous three months," she said.
Glycemic control of these patients was determined by estimation of blood glucose (fasting and random) and glycosylated haemoglobin (HbA1c).
The company added that thanks to the test, clinicians will be able to identify people with a higher versus lower likelihood of progressing to Type 2 diabetes at any given level of fasting plasma glucose (FPG) or glycosylated haemoglobin (HbA1c).
Inclusion criteria were: type 2 diabetes, age range 30-65, HbA1c (glycosylated haemoglobin) of 6-8% and fasting blood sugar (FBG) levels of 126-160mg/dl.
Glycaemic control was assessed using fasting plasma glucose, fructosamine and glycosylated haemoglobin. Biochemical parameters were compared using students't test, Pearson's correlation coefficient and analysis of variance.
The companies said that these results of the Phase 3b clinical study showed that the addition of ONGLYZA 5 mg to ongoing insulin therapy (with or without metformin) maintained reductions of blood sugar levels (glycosylated haemoglobin levels, or HbA1c) in adult patients with type 2 diabetes compared to the addition of a placebo (with or without metformin) from 24 to 52 weeks.
FDA feels that it is important for healthcare professionals to monitor blood glucose and glycosylated haemoglobin periodically in patients receiving GnRH agonists.

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