GP1BA(redirected from Glycoprotein Ibalpha)
GP1BAA gene on chromosome 17pter-p12 that encodes the alpha subunit of the Ib-V-IX system of platelet surface membrane glycoproteins, which comprise the von Willebrand factor (vWF) receptor and mediate adhesion of platelets to injured vascular surfaces with circulation, a critical event in haemostasis. The alpha subunit provides the vWF binding site.
GP1BA polymorphisms and mutations are linked to Bernard-Soulier syndromes and platelet-type von Willebrand disease.
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