Investigating the candidacy of LPS-based glycoconjugates
to prevent invasive meningococcal disease: chemical strategies to prepare glycoconjugates
with good carbohydrate loading.
The two young Thai women reclining next to me at Chiang Mai's Snail Spa sang the praises of helix aspera muller glycoconjugates
, snail mucus for short.
According to our histochemical studies of PNA, UEA, and DBA lectins, administration of aqueous extracts of Anethum graveolens decreases glycoconjugates
with Gal/GalNAc residues in a dose-dependent manner and has no effect on glycoconjugates
with [alpha]-fucose residues.
In recent years, the main interest in this lectin family lay in their prospective application as antitumor agents that could bind specific cancer cell surface glycoconjugates
(Ueno et al.
2011) to determine the presence of glycogen, glycoproteins, glycolipids, acid mucins, acid glycoconjugates
and neutral glycoconjugates
Besides their capacity to hydrolyze starch, gut microbes have developed the ability to degrade numerous plant and host-derived glycoconjugates
(glycans) and glycosaminoglycans including cellulose, chondroitin sulfate, hyaluronic acid, mucins, and heparin.
Effect of sulfated glycoconjugates
on capacitation and the acrosome reaction of bovine and hamster spermatozoa.
Twenty-five chapters start off with a historical overview and then address such topics as electronic CD of benzene and other aromatic chromophores for determination of absolute configuration, electronic circular dichroism of supramolecular systems, protein-nucleic acid interactions, carbohydrates and glycoconjugates
, and drug discovery.
Marine organism lectins seem to be especially interesting for biological applications, because they are in small molecules, induce minor immunogenicity in host cells, possess great stability on account of their several disulfide bridges, and show high specificity for complex glycoconjugates
, such as the ones present on cell surfaces .
Specific affinity of VCC for pigalactosyl-terminated glycoconjugates
, apparently mediated by the C-terminus 15 kDa [beta]-prism lectin domain homologous to the sugar-binding domain of the plant lectin jacalin (13), was first reported from this laboratory (14).
In contrast, the sea urchin egg jelly glycoconjugates
are rich in fucose sulfate, and this was reported to be the acrosome reaction inducer (SeGall & Lennarz 1979, Hirohashi & Vacquier 2002, Vilela-Silva et al.
Specific topics include human gangliosides and bacterial lipo-oligosaccharides in the development of automminune neuropathies, biotinylated multivalent glycoconjugates
for surface coating, N-linked glycoprotein analysis using dual-extraction ultrahigh-performance liquid chromatography and electrospray tandem mass spectrometry, microarray-based study of carbohydrate-protein building, metabolics in glycomics, extraction of chondroitin/dermatan sulfate glycosaminoglycans from connective tissue for mass spectrometric analysis, and characterization of polysaccharides using mass spectrometry for bacterial serotyping.