On the basis of product type, the lipids market has been segmented into sphingomyelin, cholesterol, monoglycerols, diacylglycerol, fatty acids, and
glycerophospholipid. The report on lipids market further segments glycerol phospholipids into phosphoserines, phosphocholines, phosphatidic acid, MPEGlyated phospholipids, phospholipids with heterogeneous chain, phosphoglycerols with heterogeneous chain, and phosphoethanolamines.
We extracted the pathways in which at least three compounds changed significantly (p<0.05); these included the citric acid cycle,
glycerophospholipid metabolism, cysteine metabolism, protein digestion and absorption, nicotinate and nicotinamide metabolism, purine metabolism, pentose phosphate metabolism, and polyamine metabolism pathways (Table 3).
Serine protease is known to activate toxins such as aerolysin and
Glycerophospholipid Cholestrol acyl transferase (GCAT).
Epithelial cell signaling in Helicobacter pylori, infection 2%
Glycerophospholipid metabolism 2% Glioma 2% Type II diabetes mellitus 2% Nicotinate and nicotinamide metabolism 1% MAPK signaling pathway 8% Regulation of actin cytoskeleton 7% Calcium signaling I pathway 6% Endocytosis 6% Wnt signaling pathway 5% Neurotrophin signaling pathway 4% Axon guidance 4% Cell adhesion molecules (CAMs) 4% Colorectal cancer 3% T cell receptor signaling pathway 3% TGF signaling 3% pathway Toll-like receptor signaling pathway 3% Adherens junction 3% Melanoma 3% B cell receptor signaling pathway 3% Small cell lung cancer 3% Long-term depression 3% Pancreatic cancer.
Pathways emerging from the lipid metabolism-related genes included those for alkane and fatty alcohol production and
glycerophospholipid metabolism.
It is the smallest (molecular weight: 430-480 Da) and the simplest bioactive
glycerophospholipid derived from membrane phospholipids [1, 2].
In addition, pathway analysis revealed that EGCG was involved in the regulation of the lipid and glucose metabolism, including insulin signaling pathway, Type II diabetes mellitus,
glycerophospholipid metabolism, and adipocytokine signaling pathway.
[24], through a genome-wide association study, found that the CDK17 can be mapped to the
glycerophospholipid metabolism pathway.
[23] Five metabolic pathways were identified, namely, phenylalanine and tyrosine metabolism, leucine degradation, tryptophan metabolism, sphingolipid metabolism, and
glycerophospholipid metabolism.
12 significantly differential endogenous metabolites and 4 pathways such as purine metabolism,
glycerophospholipid metabolism, amino sugar and nucleotide sugar metabolism, and linoleic acid metabolism play important roles in pathogenesis of hypertension and efficacy mechanism of Rhizoma Alismatis.
Stangl, "High dietary levels of a conjugated linoleic acid mixture alter hepatic
glycerophospholipid class profile and cholesterol-carrying serum lipoproteins of rats," Journal of Nutritional Biochemistry, vol.