glutathione reductase

(redirected from Glutathione-disulfide reductase)

glu·ta·thi·one re·duc·tase

an enzyme that catalyzes the reaction of glutathione disulfide with NADH (or NADPH), forming two glutathiones and NAD+ (or NADP+); involved in many redox reactions; a deficiency can cause hemolysis with oxidative stress.


reduced glutathione (GSH), a tripeptide containing glutamic acid, cysteine and glycine, which serves as a reducing agent in many biochemical reactions, being converted to oxidized glutathione (GSSG) in which the cysteine residues of two glutathione molecules are connected by a disulfide bridge. Reduced glutathione is important in protecting erythrocytes from oxidation and hemolysis; deficiency causes sensitivity to oxidant drugs.

glutathione peroxidase
a selenium-containing enzyme whose blood level is a good indicator of the selenium status of the animal; occurs in a plasma form, an enzyme with specificity for phospholipids, and an intracellular form. Called also GPx.
glutathione reductase
a flavin enzyme involved in the defense of the erythrocyte against hemolysis. A partial deficiency occurs relatively frequently but is due to a deficiency of riboflavin; called also GR.