glutathione reductase

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glu·ta·thi·one re·duc·tase

an enzyme that catalyzes the reaction of glutathione disulfide with NADH (or NADPH), forming two glutathiones and NAD+ (or NADP+); involved in many redox reactions; a deficiency can cause hemolysis with oxidative stress.


reduced glutathione (GSH), a tripeptide containing glutamic acid, cysteine and glycine, which serves as a reducing agent in many biochemical reactions, being converted to oxidized glutathione (GSSG) in which the cysteine residues of two glutathione molecules are connected by a disulfide bridge. Reduced glutathione is important in protecting erythrocytes from oxidation and hemolysis; deficiency causes sensitivity to oxidant drugs.

glutathione peroxidase
a selenium-containing enzyme whose blood level is a good indicator of the selenium status of the animal; occurs in a plasma form, an enzyme with specificity for phospholipids, and an intracellular form. Called also GPx.
glutathione reductase
a flavin enzyme involved in the defense of the erythrocyte against hemolysis. A partial deficiency occurs relatively frequently but is due to a deficiency of riboflavin; called also GR.
References in periodicals archive ?
SOD: Superoxide dismutase, GR: Glutathione reductase, Sham-V: Sham-operated group receiving vehicle (distilled water; 0.
What accounts for this study is the function and responsibility of the 2 enzymes: glutathione reductase and catalase which are essential for many physiological responses of the body (7).
The supernatant obtained were maintained in an ice bath and used for the estimation of total protein, lipid peroxidation, glutathione reductase, reduced glutathione, glutathione peroxidase and superoxide dismutase.
The enzyme activities such as catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GPx), glutathione-S-transferase (GST), myeloperoxidase (MPO), carbonic anhydrase (CA), glucose-6-phosphate dehydrogenase (G6PD) and lactate dehydrogenase (LDH) were assayed in appropriately diluted stomach tissue homogenates.
Calorimetric techniques were used in the estimation of enzymes as per standard procedures for glutathione peroxidase (GSHx) [17], glutathione reductase (GSHr) [18], catalase (CAT) [19], lipid peroxidation (LPO) [20], and superoxide dismutase (SOD) [21].
There was a reduction in the superoxide dismutase, guaiacol peroxidase and glutathione reductase enzymatic activity of the natural coffee as compared to the pulped natural coffee during the drying period.
Enzymatic systems: In mammalian cells, the enzymatic defense system consists mainly of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (9, 20, 47, 48).
Detoxification of ROS produces the oxidized metabol ite glutathione disulfide (GSSG), which can be reduced back to GSH through the action of glutathione reductase.
These are superoxide dismutase, glutathione -S-transferase, glutathione peroxidase, glutathione reductase, catalase and cytochrome oxidase.
mexicana has no genes for glutathione reductase (GR), thioredoxin reductase (TrxR), catalase and selenocysteine-containing glutathione peroxidase which are responsible for intracellular thiol redox homeostasis in mammals (4).
In view of these reports, it was felt necessary to study the effect of DDC administration on the levels of glutathione reductase and reduced glutathione in liver and erythrocytes and serum ceruloplasmin of rats.
Keywords: Oxidative Stress, Mud Therapy, Superoxid-Dismutase, Glutathione Reductase

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