excitotoxicity

(redirected from Glutamate-induced neurotoxicity)

excitotoxicity

(ek-sī'tō-tok-sis'i-tē),
Neuronal death resulting from increased intracellular glutamate; neuronal ischemia leads to ATP loss and depolarization, with glutamate release from synapses, and subsequent overstimulation leading to sodium and calcium ion gate porosity.

excitotoxicity

Neurology Neuronal injury caused by excessive release of excitatory neurotransmitters–glutamate and aspartate causing damage to nerve and glial cells, which occurs in diverse neurologic diseases that may be acute–eg hypoglycemia, seizures, stroke, or trauma or chronic neurodegenerative disease–eg AIDS-dementia complex, amyotrophic lateral sclerosis, Huntington's disease, and possibly Alzheimer's disease
References in periodicals archive ?
Pyrroloquinoline quinone against glutamate-induced neurotoxicity in cultured neural stem and progenitor cells.
Guo et al., "Pyrroloquinoline quinone against glutamate-induced neurotoxicity in cultured neural stem and progenitor cells," International Journal of Developmental Neuroscience, vol.
Glutamate-induced neurotoxicity may be caused by glutamate and NMDA receptors, which could produce oxidative damage, thus leading to apoptosis [24].
Persicarin from water dropwort ( Oenanthe javanica ) protects primary cultured rat cortical cells from glutamate-induced neurotoxicity. Phytother Res 2010;24:913-8.
MeCbl also has neuronal protection including promoting injured nerve and axonal regeneration [9,10] and confronting against glutamate-induced neurotoxicity [9,11].
Thus, the present study demonstrated the neuroprotective effect of insulin against glutamate-induced neurotoxicity in differentiated SH-SY5Y neuronal cells that express insulin receptor by multiple mechanisms involving reduction in glutamate-induced cell loss, prevention of apoptosis, and reducing the production of reactive oxygen species.
Saitoh et al., "Attenuation by PACAP of glutamate-induced neurotoxicity in cultured retinal neurons," Brain Research, vol.
These finding may explain the neuroprotective mechanism of minocycline in models of global and focal cerebral ischemia, the R6/2 model of Huntington's disease, as well as glutamate-induced neurotoxicity in mixed neuronal/ glial cultures (9).
* Aripiprazole inhibits glutamate-induced neurotoxicity and, in contrast to haloperidol, increases BDNF, glycogen synthase kinase (GSK)-1[beta], and the anti-apoptotic protein Bc1-2.
platyphylla bark and platyphylloside against glutamate-induced neurotoxicity in HT22 hippocampal cells were evaluated (Table 1).
Attenuation of glutamate-induced neurotoxicity in chronically ethanol-exposed cerebellar granule cells by NMDA receptor antagonists and ganglioside GM l.

Full browser ?