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Any of a family of enzymes that transfer d-glucuronate to the acceptor named, forming glucuronosides, for example, UDPglucuronate-bilirubin glucuronosyltransferase.
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Nrf2 is a basic leucine zipper-containing transcription factor that activates phase Il/detoxifying and many other genes through the cis-antioxidant response element (ARE), which contains a conserved core sequence (5'-A/GTGAC/GNNNGCa/c-3') located in the promoter region [59-61], including NAD(P)H:quinone oxidoreductase 1 (NQO1), glutathione S-transferase (GST), heme oxigenase-1 (HO-1), glutathione peroxidase (GSH-Px), gluta-matecysteine ligase (GCL), CAT, SOD, uridine diphosphate-glucuronosyltransferase glucuronosyltransferase, and the thioredoxin/peroxiredoxin system, which plays a crucial role in cell defense by improving the removal of ROS and, thus, has a protective role against oxidative stress [62].
To identify genetic variants that may explain variation in response (efficacy or toxicity) to ticagrelor a recent GWAS ofpatients in PLATO identified genetic variants in SLC01B1 and UDP glucuronosyltransferase family 2 member B7 (UGT2B7) that affected ticagrelor and active metabolite levels; however, neither gene's variants were associated with bleeding or ischemic events in the ticagrelor-treated arm (56).
2]); UGT, uridine 5'-diphospho- glucuronosyltransferase enzyme inducers (eg, rifampin, phenytoin, phenobarbital, ritonavir).
There were 53 DEGs enriched in this pathway, and these included the up-regulated DEGs encoding UDP glucuronosyltransferase (UGT) and the down-regulated DEGs encoding 17[beta]-hydroxysteroid dehydrogenases, 3-oxo-5-beta-steroid 4-dehydrogenase, 3-oxo-5-alpha-steroid 4-dehydrogenase 1, and estronesulfotransferase.
Recent studies have investigated that after tea consumption, catechins are metabolized and transformed as sulfated, methylated, or glucuronidated derivatives by enzymes such as sulfotranferase, catechol-O-methyltransferase and glucuronosyltransferase respectively [16] and it has been hypothesized that breakdown of flavonoids into smaller phenolic acids takes place within the colon from bacterial degradation, absorption occurs through the small intestine.
b) 2D6, (c) and 2C9, (d) and uridine 5'-diphosphate glucuronosyltransferase (e) are increased during pregnancy, whereas the activities of CYP1A2 (f) and 2C19 (g) are decreased.
9] Several hypotheses have been proposed for breast milk jaundice, including the presence of UDP glucuronosyltransferase inhibitor, [beta] glucuronidase or yet unidentified of bilirubin & results in hyperbilirubinemia.
Effect of Cigarette Smoke on UDP- Glucuronosyltransferase Activity and Cytochrome P450 Content in Liver, Lung and Kidney Microsomes in Mice.
Clofibrate as a hypolipidemic drug is a glucuronosyltransferase inducer which accelerates bilirubin elimination.
Asi mismo, existe evidencia que soporta el uso de dupletas que incluyen irinotecan (27, 28) y pemetrexed (29-31); no obstante, para el primero de estos dos casos, la eficacia solo ha sido probada en Japon y podria estar limitada por la variabilidad genetica relacionada con los polimorfismos del transportador de membrana ABCB1 (ATP-binding cassette sub-family B member 1) y de la UGT1A1 (uridine diphosphate glucuronosyltransferase 1A1), relacionada con el metabolismo del inhibidor de topoisomerasa (32).
A pharmacogenetic study of uridine diphosphate glucuronosyltransferase 2B7 in patients receiving morphine.