glucuronide

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glucuronide

 [gloo-ku´ron-īd]
any glycosidic compound of glucuronic acid; glucuronides, which are generally inactive, constitute the major proportion of the metabolites of many phenols, alcohols, and carboxylic acids.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

glu·cu·ro·nide

(glū-kū'rōn-īd),
A glycoside of glucuronic acid; many foreign chemicals, as well as catabolic products of normal body constituents (for example, steroid hormones), are commonly excreted in the urine as d-glucuronides, the conjugation taking place in the liver.
Synonym(s): glucuronoside
Farlex Partner Medical Dictionary © Farlex 2012

glu·cu·ro·nide

(glū-kyūr'ō-nīd)
A glycoside of glucuronic acid; many foreign chemicals, as well as catabolic products of normal body constituents (e.g., steroid hormones), are commonly excreted in the urine as d-glucuronides, the conjugation taking place in the liver.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
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Simultaneous determination of mycophenolic acid and its glucuronide in human plasma using a simple high-performance liquid chromatography procedure.
Validation of a rapid and sensitive liquid chromatography-tandem mass spectrometry method for free and total mycophenolic acid
Hydrolysis of steroid glucuronides with [beta]-glucuronidase preparations from bovine liver, Helix pomatia, and E.
Rapid HPLC-electrospray tandem mass spectrometric assay for urinary testosterone and dihydrotestosterone glucuronides from patients with benign prostate hyperplasia
Properties of acyl glucuronides: implications for studies of the pharmacokinetics and metabolism of acidic drugs.
Stability of 11-nor-[[DELTA].sup.9]-carboxy-tetrahydrocannabinol glucuronide in plasma and urine assessed by liquid chromatography--tandem mass spectrometry
The stability of the glucuronides of some steroids in dried blood spots stored for 1 week at room temperature, compared with aliquots maintained in a freezer (-20 [degrees]C), was verified (Fig.
Oral testosterone administration detected by testosterone glucuronidation measured in blood spots dried on filter paper
We recently characterized two further metabolites of MPA, including an acyl glucuronide metabolite (AcMPAG), in the plasma of liver, kidney, and heart transplant recipients receiving MMF (4).
Determination of the acyl glucuronide metabolite of mycophenolic acid in human plasma by HPLC and Emit
[beta]-Glucuronidase and the hydrolysis of glucuronides. In: Dutton GJ, ed.
Efficient cleavage of conjugates of drugs or poisons by immobilized [beta]-glucuronidase and arylsulfatase in columns
Biosynthesis of these steroid molecules in human beings is constant, and in the urine the normal testosterone glucuronide and epitestosterone glucuronide ratio (T/E) ranges between 0.4 and 2 (bimodal variation is in line with genetic polymorphism).
THE USE OF ANABOLIC ANDROGENIC STEROIDS: A FOCUS ON POLYPHARMACY/UPOTREBA ANABOLICKIH ANDROGENIH STEROIDA SA FOKUSOM NA POLIFARMACIJU
Schematic overview of the PBPK model for BPA, BPS, BPF, and BPAF and their glucuronides and sulfates (PBPK-compartments in gray, single-compartment submodules with dotted lines).
Physiologically Based Pharmacokinetic (PBPK) Modeling of the Bisphenols BPA, BPS, BPF, and BPAF with New Experimental Metabolic Parameters: Comparing the Pharmacokinetic Behavior of BPA with Its Substitutes
Future investigations are required to clarify the mechanism allowing kidney extracts to convert bile acids into acyl glucuronides in the absence of the UGT1A3 protein.
Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions
Our results showed that compounds 6 and 10, which contain a glucuronide at position 7 in the A ring and di-hydroxyl groups in the B ring of the flavonol skeleton, exhibited the highest AGE inhibitory activity.
Evaluation of Aldose Reductase, Protein Glycation, and Antioxidant Inhibitory Activities of Bioactive Flavonoids in Matricaria recutita L. and Their Structure-Activity Relationship
Influence of nonsynonymous polymorphism of UGT1A8 and UGT2B7 metabolizing enzymeson the formation of phenolic and acly glucuronides of mycophenolic acid.
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Since the glucuronides of morphine and other opiates have been
Drugs in hair. Part I. Metabolisms of major drug classes

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