glucuronide

(redirected from Glucuronides)
Also found in: Dictionary, Encyclopedia.

glucuronide

 [gloo-ku´ron-īd]
any glycosidic compound of glucuronic acid; glucuronides, which are generally inactive, constitute the major proportion of the metabolites of many phenols, alcohols, and carboxylic acids.

glu·cu·ro·nide

(glū-kū'rōn-īd),
A glycoside of glucuronic acid; many foreign chemicals, as well as catabolic products of normal body constituents (for example, steroid hormones), are commonly excreted in the urine as d-glucuronides, the conjugation taking place in the liver.
Synonym(s): glucuronoside

glucuronide

/glu·cu·ron·ide/ (gloo-ku´ron-īd) any glycosidic compound of glucuronic acid; they are common soluble conjugates formed as a step in the metabolism and excretion of many toxins and drugs, such as phenols and alcohols.

glu·cu·ro·nide

(glū-kyūr'ō-nīd)
A glycoside of glucuronic acid; many foreign chemicals, as well as catabolic products of normal body constituents (e.g., steroid hormones), are commonly excreted in the urine as d-glucuronides, the conjugation taking place in the liver.

glucuronide

any glycosidic conjugate of glucuronic acid; glucuronides, which are generally inactive, constitute the major proportion of the metabolites of many phenols, alcohols and carboxylic acids.
References in periodicals archive ?
single-dose study [219] where oxazepam and temazepam glucuronides were
Based on the descending order of mass response, glucuronide M51 was identified as the major metabolite, followed by M5-3 and M5-2.
In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors alpha and beta.
This suggested that conjugated metabolites were in the form of glucuronides.
The glucuronides were the major excreted form, with a total excretion equal to 1.
First, the urine samples were treated with [beta]-glucuronidase to hydrolyze the glucuronide conjugates.
The major peak eluting earlier was considered to be puerarin 7-O-[beta]-glucuronide and the latter puerarin 4'-O-[beta]-glucuronide on the basis of comparison of the relative retention times of daidzein glucuronides (Clarke et al.
Intestinal bacteria are often responsible for the deconjugation of biliary glucuronides into the parental xenobiotic (50), and indeed most of the fecal radioactivity was detected as unchanged BPA.
11-OH-THC, CBD, and CBN could be present as glucuronide or sulfate conjugates, but commercial conjugated standards are unavailable and thus could not be monitored in our method.
It has been established in rodents, for example, that BPA is extensively metabolized to glucuronides (57-98%) and possibly sulfate conjugates (0-4%), leaving 1-12% unmetabolized BPA (18,19), thereby complicating both qualitative and quantitative determinations.
Based on MS peak areas and ranking in the 1-h and 3-h samples, the main XLR-11 metabolites were 2'-carboxy-XLR-11 (M27), UR-144 pentanoic acid (M28), 5-hydroxy-UR-144 (M29), 2'-carboxyUR-144 pentanoic acid (M15), and the 3 hydroxy XLR-11 glucuronides (M21, M18, M20).
Biliary excretion of flavopiridol and its glucuronides in the isolated perfused rat liver: role of multidrug resistance protein 2 (Mrp2).