glucuronide

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glucuronide

[gloo-ku´ron-īd]

any glycosidic compound of glucuronic acid; glucuronides, which are generally inactive, constitute the major proportion of the metabolites of many phenols, alcohols, and carboxylic acids.

glu·cu·ro·nide

(glū-kū'rōn-īd),

A glycoside of glucuronic acid; many foreign chemicals, as well as catabolic products of normal body constituents (for example, steroid hormones), are commonly excreted in the urine as d-glucuronides, the conjugation taking place in the liver.

Synonym(s): glucuronoside

glucuronide

/glu·cu·ron·ide/ (gloo-ku´ron-īd) any glycosidic compound of glucuronic acid; they are common soluble conjugates formed as a step in the metabolism and excretion of many toxins and drugs, such as phenols and alcohols.

glu·cu·ro·nide

(glū-kyūr'ō-nīd)

A glycoside of glucuronic acid; many foreign chemicals, as well as catabolic products of normal body constituents (e.g., steroid hormones), are commonly excreted in the urine as d-glucuronides, the conjugation taking place in the liver.

glucuronide

any glycosidic conjugate of glucuronic acid; glucuronides, which are generally inactive, constitute the major proportion of the metabolites of many phenols, alcohols and carboxylic acids.

References in periodicals archive ?

single-dose study [219] where oxazepam and temazepam glucuronides were

Drugs in hair. Part I. Metabolisms of major drug classes

Based on the descending order of mass response, glucuronide M51 was identified as the major metabolite, followed by M5-3 and M5-2.

Wedelolactone metabolism in rats through regioselective glucuronidation catalyzed by uridine diphosphate-glucuronosyltransferases 1As (UGT1As)

In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors alpha and beta.

Comment on "in vitro effects of bisphenol a [beta]-D-glucuronide (BPA-G) on adipogenesis in human and murine preadipocytes"

This suggested that conjugated metabolites were in the form of glucuronides.

Metabolism of halogenated hydroxyquinolines

The glucuronides were the major excreted form, with a total excretion equal to 1.

Absorption and metabolism of milk thistle flavanolignans in humans

First, the urine samples were treated with [beta]-glucuronidase to hydrolyze the glucuronide conjugates.

Urinary concentrations of bisphenol a and 4-Nonylphenol in a human reference population

The major peak eluting earlier was considered to be puerarin 7-O-[beta]-glucuronide and the latter puerarin 4'-O-[beta]-glucuronide on the basis of comparison of the relative retention times of daidzein glucuronides (Clarke et al.

Tissue distribution of puerarin and its conjugated metabolites in rats assessed by liquid chromatography-tandem mass spectrometry

Intestinal bacteria are often responsible for the deconjugation of biliary glucuronides into the parental xenobiotic (50), and indeed most of the fecal radioactivity was detected as unchanged BPA.

Biotransformations of bisphenol A in a mammalian model: answers and new questions raised by low-dose metabolic fate studies in pregnant CD1 mice. (Research)

11-OH-THC, CBD, and CBN could be present as glucuronide or sulfate conjugates, but commercial conjugated standards are unavailable and thus could not be monitored in our method.

Urinary cannabinoid disposition in occasional and frequent smokers: is THC-glucuronide in sequential urine samples a marker of recent use in frequent smokers?

It has been established in rodents, for example, that BPA is extensively metabolized to glucuronides (57-98%) and possibly sulfate conjugates (0-4%), leaving 1-12% unmetabolized BPA (18,19), thereby complicating both qualitative and quantitative determinations.

Bisphenol A levels in human urine. (Research)

Based on MS peak areas and ranking in the 1-h and 3-h samples, the main XLR-11 metabolites were 2'-carboxy-XLR-11 (M27), UR-144 pentanoic acid (M28), 5-hydroxy-UR-144 (M29), 2'-carboxyUR-144 pentanoic acid (M15), and the 3 hydroxy XLR-11 glucuronides (M21, M18, M20).

First metabolic profile of XLR-11, a novel synthetic cannabinoid, obtained by using human hepatocytes and high-resolution mass spectrometry

Biliary excretion of flavopiridol and its glucuronides in the isolated perfused rat liver: role of multidrug resistance protein 2 (Mrp2).

Choleretic effects of yarrow (Achillea millefolium s.l.) in the isolated perfused rat liver