glucose-6-phosphate dehydrogenase

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dehydrogenase

 [de-hi´dro-jen-ās″]
an enzyme that mobilizes the hydrogen of a substrate so that it can pass to a hydrogen acceptor.
glucose-6-phosphate dehydrogenase an enzyme necessary for the oxidation of glucose-6-phosphate, an intermediate in carbohydrate metabolism. Hereditary deficiency of this enzyme in the erythrocytes is associated with a tendency toward hemolysis upon ingestion of certain antimalarial agents and sulfonamide drugs and fava beans (see favism.
lactate dehydrogenase (LDH) an enzyme that catalyzes the interconversion of lactate and pyruvate. It is widespread in tissues and is particularly abundant in kidney, skeletal muscle, liver, and myocardium. It appears in elevated concentrations when these tissues are injured.

glu·cose-6-phos·phate de·hy·dro·gen·ase

(glū'kōs fos'fāt dē'hī-droj'en-ās),
An NADP+-dependent enzyme catalyzing the dehydrogenation of d-glucose 6-phosphate to 6-phospho-d-glucono-δ-lactone, this reaction initiating the pentose shunt. A deficiency of this enzyme can lead to severe hemolytic anemia and favism. A deficiency of the leukocyte enzyme prevents respiratory burst in neutrophils.

glucose-6-phosphate dehydrogenase (G-6-PD)

an important enzyme in the PENTOSE PHOSPHATE PATHWAY for carbohydrate metabolism, catalysing the oxidation of glucose 6-phosphate in the presence of NADP coenzyme, giving 6-phosphogluconolactone and NADPH. G-6-PD of blood erythrocytes is of particular interest because a decrease in its activity can lead to the condition called FAVISM.
References in periodicals archive ?
From interpretation of data obtained in this study, evaluation of plasma levels of hepatic enzymes such as Lactate and Glucose-6-phosphate-dehydrogenases, Acid and Alkaline Phosphatases, Alanine and Aspartate Transaminases in Nigerians affected with hematological malignancies could assist in studying the prognostication of hematological malignancies.

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