In addition, the mRNA expression levels of phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase
(G-6-Pase), in the liver were also significantly upregulated in the high-fat diet induced obese rats (Figure 1).
The effects of N-alkylmaleimides on the activity of rat liver glucose 6-phosphatase
. Biochem J 1981; 194:319-325.
In hepatocytes, canonical Wnt3a stimulation decreases key enzymes of gluconeogenesis such as phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase
Consequently, FoxO1 is not capable of enhancing the expression of two vast gluconeogenic executors, PCK1 (phosphoenolpyruvate carboxykinase 1) and G6PC (glucose 6-phosphatase
Transcripts for phosphoenolpyruvate carboxykinase (Pepck) and glucose 6-phosphatase
(G6pase), which encode gluconeogenic enzymes, were also significantly reduced in the liver of KO mice (Figure 2C).
There Is Elevated Expression of Glucose 6-Phosphatase
, Acetyl Co-A Carboxylase, and Increased Acyl Glycerols in the Liver of db/db Mice.