Glucocorticoid therapy

Glucocorticoid therapy

Treatment using corticoids that are anti-inflammatory and immunosuppressive.
Mentioned in: Myelofibrosis
References in periodicals archive ?
The product is approved in adults for the same indications as Eli Lilly's Forsteo and is used for the treatment of osteoporosis in postmenopausal women and in men at increased risk of fracture and treatment of osteoporosis associated with sustained systemic glucocorticoid therapy in women and men at increased risk for fracture.
Terrosa, Eli Lilly's Forsteo, is used for the treatment of osteoporosis in postmenopausal women and in men at increased risk of fracture and treatment of osteoporosis associated with sustained systemic glucocorticoid therapy in women and men at increased risk for fracture.
While the current practice of using glucocorticoid therapy shows life-saving benefits for the preterm infant, the researchers say that combining them with antioxidants would overcome potential safety concerns associated with existing treatment.
Plasmapheresis is used as an empirical therapy in patients not responding to glucocorticoid therapy. [6,7] Few regimens have been proposed to prevent relapses which include usage of Mycophenolate Mofetil, Rituximab [8] or a combination of Glucocorticoids plus Azathioprine.
Initial clinical data suggest that vamorolone has the anti-inflammatory efficacy of steroids with reduced steroid-associated safety concerns, which would represent a significant improvement over current standard of care glucocorticoid therapy in patients with Duchenne muscular dystrophy (DMD), vamorolone's lead indication.
"These results are relevant in a population in whom progression can quickly result in substantial neurologic symptoms, functional impairment, and the need for glucocorticoid therapy," the study investigators reported.
Long-term glucocorticoid therapy is the second leading cause of AVN, following traumatic events.
Amgen announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted a positive opinion for the marketing authorization of Prolia for the treatment of bone loss associated with long-term systemic glucocorticoid therapy in adult patients at increased risk of fracture.
There is no consensus for appropriate dose and duration of glucocorticoid therapy [4, 14, 15].
Graziadio et al., "Effect of once-daily, modified-release hydrocortisone versus standard glucocorticoid therapy on metabolism and innate immunity in patients with adrenal insufficiency (DREAM): a single-blind, randomised controlled trial," The Lancet Diabetes & Endocrinology, vol.
However, glucocorticoid therapy cannot reduce the high expression of TGF[beta] in asthmatic patients, suggesting that glucocorticoid therapy alone cannot inhibit the factors involved in airway remodeling [4].
The question now is how should one proceeds when starting abiraterone therapy for patients who had received systemic glucocorticoid therapy? Long-term exposure to glucocorticoid produces a variety of adverse events including increased risk of hyperglycemia, bone metabolism, immunosuppression, and cognitive impairment [13-17].

Full browser ?