NR3C1

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NR3C1

A gene on chromosome 5q31.3 that encodes a glucocorticoid receptor, which acts as either a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, or as a regulator of other transcription factors.

Molecular pathology
NR3C1 mutation are associated with generalised glucocorticoid resistance.
References in periodicals archive ?
brain-derived neurotrophic factor, glucocorticoid receptor, membrane-bound catechol-O-methyl transferase and the glutamatergic genes), and anatomical sites (the hypothalamus, nucleus accumbens and prefrontal cortex) in individuals affected with a range of behavioural disorders, such as drug addiction/abuse, [23] eating disorders and obesity, [24] major depressive disorder, bipolar disorder, schizophrenia, psychopathy and suicide.
Glucocorticoid-induced transcript 1 gene deficiency impaired the effects of glucocorticoids on glucocorticoid receptor and mitogen-activated protein kinase phosphatase-1
Nuclear factor-kappaB and glucocorticoid receptor alpha mediated mechanisms in the regulation of systemic and pulmonary inflammation during sepsis and acute respiratory distress syndrome.
Glucocorticoids act, in part, via negative feedback of the HPA axis through the hippocampus, which is densely concentrated with glucocorticoid receptors. Similarly, rodent studies have shown that exposure to stress or high doses of corticosterone (a rodent glucocorticoid) produces deficits in hippocampus-dependent spatial memory tasks.
Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells.
Kino, "Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications," The FASEB Journal, vol.
Amrani, "CD38 expression is insensitive to steroid action in cells treated with tumor necrosis factor-[alpha] and interferon-y by a mechanism involving the up-regulation of the glucocorticoid receptor ft isoform," Molecular Pharmacology, vol.
Cidlowski, "Glucocorticoid receptor signaling in health and disease," Trends in Pharmacological Sciences, vol.
Physalin B, although with secosteroidal chemical structure, did not act through the glucocorticoid receptor in macrophages, which means its structure group different from glucocorticoid is the active core.
Differential control of glucocorticoid receptor hormone-binding function by tetratricopeptide repeat (TPR) proteins and the immunosuppressive ligand FK506.
On the other hand, high doses of cortisol decreased proliferation through glucocorticoid receptor signaling, with no effect on gliogenesis [49].
Glucocorticoid receptor (GR) also becomes influential in dry AMD progression.

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