glutathione peroxidase

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glu·ta·thi·one per·ox·i·dase

an enzyme that catalyzes the reaction of two glutathiones with H2O2, forming glutathione disulfide and two water molecules; a crucial enzyme in hydrogen peroxide detoxification.

glutathione peroxidase

An antioxidant enzyme found in many mammalian cells, including red blood cells. Deficiencies of the enzyme have been linked to an increased risk of acute coronary syndrome.


reduced glutathione (GSH), a tripeptide containing glutamic acid, cysteine and glycine, which serves as a reducing agent in many biochemical reactions, being converted to oxidized glutathione (GSSG) in which the cysteine residues of two glutathione molecules are connected by a disulfide bridge. Reduced glutathione is important in protecting erythrocytes from oxidation and hemolysis; deficiency causes sensitivity to oxidant drugs.

glutathione peroxidase
a selenium-containing enzyme whose blood level is a good indicator of the selenium status of the animal; occurs in a plasma form, an enzyme with specificity for phospholipids, and an intracellular form. Called also GPx.
glutathione reductase
a flavin enzyme involved in the defense of the erythrocyte against hemolysis. A partial deficiency occurs relatively frequently but is due to a deficiency of riboflavin; called also GR.