GRIA4

(redirected from GluA4)

GRIA4

A gene on chromosome 11q22 that encodes a member of the excitatory neurotransmitter glutamate receptor family, which are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and function as ligand-activated cation channels.

Molecular pathology
Weak data have linked GRIA4 mutations to schizophrenia.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Mentioned in ?
References in periodicals archive ?
In bioengineered mice that the Stanford team studied with Wayne Frankel, PhD, of the Jackson Laboratory in Bar Harbor, Maine, this circuit is broken because the GluA4 receptor, a protein component of cells critical to the stimulation of nRT cells, is missing.
It is composed of four subunits: GluA1, GluA2, GluA3, and GluA4, which form a heterotetramer.
GluA2, GluA3, and possibly GluA4 subunits of AMPAR are present in SGN afferent dendrites in the adult cochlea [38], and the GluA2 subunit determines the key biophysical properties of GluAs in vivo [39].
These receptors are composed of four types of subunits: GluA1, GluA2, GluA3 and GluA4 [141].