GRIA1

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GRIA1

A gene on chromosome 5q33 that encodes a member of the excitatory neurotransmitter glutamate receptor family, which are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and function as ligand-activated cation channels.
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We also showed that the GluA1 subunit of the AMPA receptor which is the main mediator of excitatory transmission in the visual cortex is important for homeostatic plasticity.
Cav1.2 L-type Ca2+ channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca(v)1.3 channels.
Additionally, [beta]-AR activation increases the expression of the a-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptor subunit GluA1, one of the four subunits of the AMPA receptor for glutamate (12).
In the GluA1 locus, 3 alleles (a, b, c) have been identified, in GluB1 6 alleles (a, b, c, d, e, k), and in Glu-D1 2 alleles (a, d) (Table 2).
As noted, E-LTP induction is dependent on the rapid trafficking of AMPA receptors containing the GluA1 subunit to the postsynaptic membrane [51, 150], and recent work has demonstrated that glutamate receptor trafficking is regulated by clock-gated signaling pathways.
Lalchandani et al., "Soluble ICAM-5, a product of activity dependent proteolysis, increases mEPSC frequency and dendritic expression of GluA1," PLOS ONE, vol.
Lawrence, "Catalogue of alleles for the complex gene loci GluA1, GluB1, GluD1, which code for the highmolecular-weight subunits of glutenin in hexaploid wheat," Cereal Research Communications, vol.
CaMKIIalpha knockdown decreases anxiety in the open field and low serotonin-induced upregulation of GluA1 in the basolateral amygdala.
In our results, we detected significant elevation of GluA2/ 3 expression in the hippocampus, but not GluA1. This suggested for insertion or synthesis of GluA2-containing AMPA receptors, which might act in replacement of GluA2-lacking AMPA receptors that are recruited in acute stress phases.
The diffusion constant of GluA1 drops as the subunit reaches a hyaluronan-enriched area.
While CaMKII appears to have multiple functions in synaptic plasticity, phosphorylation of GluA1 receptors to regulate their trafficking and signaling appears to be critical for LTP [7].
More recent studies revealed that palmitoylation of GluA1 subunit requires its dynamic anterograde transport from the ER to the Golgi apparatus, while GluA2 subunits are palmitoylated by the ER-resided DHHC2 [172].