GRIA1

(redirected from GluA1)

GRIA1

A gene on chromosome 5q33 that encodes a member of the excitatory neurotransmitter glutamate receptor family, which are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and function as ligand-activated cation channels.

Mentioned in ?

References in periodicals archive ?

We also showed that the GluA1 subunit of the AMPA receptor which is the main mediator of excitatory transmission in the visual cortex is important for homeostatic plasticity.

Homeostatic plasticity in mouse visual cortex

Cav1.2 L-type Ca2+ channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca(v)1.3 channels.

Calcium Receptor and Nitric Oxide Synthase Expression in Circular Muscle of Lower Esophagus from Patients with Achalasia

Additionally, [beta]-AR activation increases the expression of the a-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptor subunit GluA1, one of the four subunits of the AMPA receptor for glutamate (12).

Adrenergic receptor [[beta].sub.3] is involved in the memory consolidation process in mice

In the GluA1 locus, 3 alleles (a, b, c) have been identified, in GluB1 6 alleles (a, b, c, d, e, k), and in Glu-D1 2 alleles (a, d) (Table 2).

Composition of High Molecular Weight Glutenin Subunits in Polish Common Wheat Cultivars (Triticum aestivum L.)

As noted, E-LTP induction is dependent on the rapid trafficking of AMPA receptors containing the GluA1 subunit to the postsynaptic membrane [51, 150], and recent work has demonstrated that glutamate receptor trafficking is regulated by clock-gated signaling pathways.

Circadian Regulation of Hippocampal-Dependent Memory: Circuits, Synapses, and Molecular Mechanisms

Lalchandani et al., "Soluble ICAM-5, a product of activity dependent proteolysis, increases mEPSC frequency and dendritic expression of GluA1," PLOS ONE, vol.

Matrix Metalloproteinase 9 in Epilepsy: The Role of Neuroinflammation in Seizure Development

Lawrence, "Catalogue of alleles for the complex gene loci GluA1, GluB1, GluD1, which code for the highmolecular-weight subunits of glutenin in hexaploid wheat," Cereal Research Communications, vol.

Marker-assisted selection for recognizing wheat mutant genotypes carrying HMW glutenin alleles related to baking quality

CaMKIIalpha knockdown decreases anxiety in the open field and low serotonin-induced upregulation of GluA1 in the basolateral amygdala.

Analgesic effects of Marasmius androsaceus mycelia ethanol extract and possible mechanisms in mice

In our results, we detected significant elevation of GluA2/ 3 expression in the hippocampus, but not GluA1. This suggested for insertion or synthesis of GluA2-containing AMPA receptors, which might act in replacement of GluA2-lacking AMPA receptors that are recruited in acute stress phases.

Recovery of Chronic Stress-Triggered Changes of Hippocampal Glutamatergic Transmission

The diffusion constant of GluA1 drops as the subunit reaches a hyaluronan-enriched area.

Proteolytic Remodeling of Perineuronal Nets: Effects on Synaptic Plasticity and Neuronal Population Dynamics

While CaMKII appears to have multiple functions in synaptic plasticity, phosphorylation of GluA1 receptors to regulate their trafficking and signaling appears to be critical for LTP [7].

Activation State-Dependent Substrate Gating in [Ca.sup.2+]/Calmodulin-Dependent Protein Kinase II

More recent studies revealed that palmitoylation of GluA1 subunit requires its dynamic anterograde transport from the ER to the Golgi apparatus, while GluA2 subunits are palmitoylated by the ER-resided DHHC2 [172].