gliotoxin


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gliotoxin

A poisonous substance produced by the fungus Aspergillus fumigatus that has been found to interfere with the ‘stickiness’ of MACROPHAGES and to inhibit the process by which the immune system recognizes transplanted tissue, infecting organisms and cancer cells as ‘foreign’.
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References in periodicals archive ?
Among other factors, it is gliotoxin -- a potent mycotoxin -- that is responsible for the pathogenicity of Aspergillus fumigatus.
Gliotoxin contamination in pre- and postfermented corn, sorghum and wet brewer's grains silage in Sao Paulo and Rio de Janeiro State, Brazil.
The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB.
Smart et al., "Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats," Gastroenterology, vol.
Hidalgo, "Metallothionein prevents neurodegeneration and central nervous system cell death after treatment with gliotoxin 6-aminonicotinamide," Journal of Neuroscience Research, vol.
Isolation and localization of the antibiotics gliotoxin produced by Gliocladium virens from alginate prill in soil and soilless media.
fumigatus produce a number of low-molecular-mass toxins, including helvolic acid, fumagillin and gliotoxin [23].
e., high transmembrane potential, no swelling) as the response to the apoptotic compound, gliotoxin [86].
Endochitinase from Gliocladium virens: Isolation, characterization, and synergistic antifungal activity in combination with gliotoxin. Phytopathology 83(3):308-313.
fumigatus toxins, including gliotoxin, helvolic acid and fumagillin (Takashi et al., 2004).