Among other factors, it is gliotoxin
-- a potent mycotoxin -- that is responsible for the pathogenicity of Aspergillus fumigatus.
contamination in pre- and postfermented corn, sorghum and wet brewer's grains silage in Sao Paulo and Rio de Janeiro State, Brazil.
The immunosuppressive fungal metabolite gliotoxin
specifically inhibits transcription factor NF-kappaB.
Smart et al., "Gliotoxin
stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats," Gastroenterology, vol.
Hidalgo, "Metallothionein prevents neurodegeneration and central nervous system cell death after treatment with gliotoxin
6-aminonicotinamide," Journal of Neuroscience Research, vol.
Isolation and localization of the antibiotics gliotoxin
produced by Gliocladium virens from alginate prill in soil and soilless media.
fumigatus produce a number of low-molecular-mass toxins, including helvolic acid, fumagillin and gliotoxin
Aflatoxin B1, ochratoxin A as well as gliotoxin
produced by the fungi belonging to A.
e., high transmembrane potential, no swelling) as the response to the apoptotic compound, gliotoxin
fumigatus toxins, including gliotoxin
, helvolic acid and fumagillin (Takashi et al., 2004).
In addition, Trichoderma virens produced gliotoxin
toxic to both R.