Gleason score

(redirected from Gleason system)

Glea·son tu·mor grade

(glē'sŏn),
a classification of adenocarcinoma of the prostate by evaluation of the pattern of glandular differentiation; the tumor grade, known as Gleason score, is the sum of the dominant and secondary patterns, each numbered on a scale of 1 to 5.

Gleason score

Oncology A value derived from the Gleason grading system which is the sum of the 2 most predominant histologic patterns seen in prostate CA.

Gleason score

A method of grading malignancy of prostate cancers, based on the pattern of glandular differentiation. Both the dominant and secondary patterns of differentiation are scored on a scale of 1 to 5, and the Gleason score, is the sum of the two scores.

Gleason,

Donald F., U.S. pathologist, 1920–.
Gleason score
Gleason tumor grade - a classification of adenocarcinoma of the prostate.
References in periodicals archive ?
Gleason's work was validated by most of the preeminent urologic pathology groups, (6-10) and the Gleason system became accepted as the preferred grading method for PCa.
Due to this diversity, the final grade as reported by the Gleason system is based on the combination of the most dominant and second most dominant patterns observed.
There are some problems with the clinical application of the Gleason system. Notification of the significant prognostic difference between prostate carcinomas with Gleason grade 3+4 and 4+3 revealed that treatment decisions using a single Gleason score misdirect the management of patients.
After examining the haematoxylin and eosin stained slides, the tumours were classified according to modified Gleason system with ISUP recommendations.
The histopathological grading and scoring by Gleason system was carried out in all cases of adenocarcinoma of prostate, criteria for the grading and scoring of needle biopsies of the prostate.
(5,6) Moreover, the differences between the original Gleason system and the 2005 ISUP Modified Gleason System make it difficult to compare data sets assessing patient outcomes in prostate cancer over time.
The Gleason system uses a score of two to 10 to analyze a tumor; a score between eight and 10 suggests an aggressive, fast-growing tumor that's probably spread beyond the prostate gland.
At McCaffrey's, a three-store New Jersey independent that has had the system for six years, managers use the Gleason system for hourly store walk-throughs.
The most critical threshold in the Gleason system is in the recognition of patterns 4 and 5.