However, this tumor's aggressiveness can be predicted to a certain extent through clinical parameters, mainly the Gleason score
, PSA, and tumor stage (TNM).
 The Gleason score
and prostate-specific antigen (PSA) level are the most important prognostic factors in prostate cancer.
Although preoperative prostate-specific antigen (PSA) levels, Gleason score
in the biopsy specimen, and clinical stages are well-established predictors of PC, identification of additional factors which can help us to better estimate and evaluate the severity of PC is expected to be useful for patient counseling.
Accordingly, all the Gleason score
information of patients was obtained from biopsy specimen.
Histopathological analysis showed adenocarcinoma with a Gleason score
of 5 (3 + 2).
The researchers in Milan have now found that low levels of testosterone indicate a patient will have a high Gleason score
(aggressive), indicating a poor outcome after treatment.
Robert's PSA was not off the charts, but his Gleason score
was also high.
The authors have also provided helpful information about patient- and cancer-related parameters associated with upgrading to Gleason score
7 or greater at surveillance biopsy.
The company added that the Medicare coverage decision extends reimbursement for Oncotype DX testing to prostate cancer patients defined as low- and very low-risk by the National Comprehensive Cancer Network (NCCN), who are eligible based on clinical and pathological factors such as prostate-specific antigen (PSA) and Gleason score
, following the 45-day notice period under Palmetto GBA's process.
(5) Furthermore, the presence of a ductal component in the tumor is reported to be associated with an aggressive disease, although the impact of the ductal component on the overall Gleason score
and PSA levels remains controversial.
From these, 43 cases with a high-grade Gleason score
and 42 cases with a low-grade Gleason score
were randomly selected.
In a new analysis, researchers compared 489 men in the study who were diagnosed with high-grade prostate cancer (a Gleason score
of 7 to 10) during the trial to 3,117 men in the study without prostate cancer.