Gleason score


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Glea·son tu·mor grade

(glē'sŏn),
a classification of adenocarcinoma of the prostate by evaluation of the pattern of glandular differentiation; the tumor grade, known as Gleason score, is the sum of the dominant and secondary patterns, each numbered on a scale of 1 to 5.

Gleason score

Oncology A value derived from the Gleason grading system which is the sum of the 2 most predominant histologic patterns seen in prostate CA.

Gleason score

A method of grading malignancy of prostate cancers, based on the pattern of glandular differentiation. Both the dominant and secondary patterns of differentiation are scored on a scale of 1 to 5, and the Gleason score, is the sum of the two scores.

Gleason,

Donald F., U.S. pathologist, 1920–.
Gleason score
Gleason tumor grade - a classification of adenocarcinoma of the prostate.
References in periodicals archive ?
However, this tumor's aggressiveness can be predicted to a certain extent through clinical parameters, mainly the Gleason score, PSA, and tumor stage (TNM).
[9] The Gleason score and prostate-specific antigen (PSA) level are the most important prognostic factors in prostate cancer.
Although preoperative prostate-specific antigen (PSA) levels, Gleason score in the biopsy specimen, and clinical stages are well-established predictors of PC, identification of additional factors which can help us to better estimate and evaluate the severity of PC is expected to be useful for patient counseling.
Accordingly, all the Gleason score information of patients was obtained from biopsy specimen.
Histopathological analysis showed adenocarcinoma with a Gleason score of 5 (3 + 2).
The researchers in Milan have now found that low levels of testosterone indicate a patient will have a high Gleason score (aggressive), indicating a poor outcome after treatment.
Robert's PSA was not off the charts, but his Gleason score was also high.
The authors have also provided helpful information about patient- and cancer-related parameters associated with upgrading to Gleason score 7 or greater at surveillance biopsy.
The company added that the Medicare coverage decision extends reimbursement for Oncotype DX testing to prostate cancer patients defined as low- and very low-risk by the National Comprehensive Cancer Network (NCCN), who are eligible based on clinical and pathological factors such as prostate-specific antigen (PSA) and Gleason score, following the 45-day notice period under Palmetto GBA's process.
(5) Furthermore, the presence of a ductal component in the tumor is reported to be associated with an aggressive disease, although the impact of the ductal component on the overall Gleason score and PSA levels remains controversial.
From these, 43 cases with a high-grade Gleason score and 42 cases with a low-grade Gleason score were randomly selected.
In a new analysis, researchers compared 489 men in the study who were diagnosed with high-grade prostate cancer (a Gleason score of 7 to 10) during the trial to 3,117 men in the study without prostate cancer.