Gleason score

(redirected from Gleason grade)

Glea·son tu·mor grade

(glē'sŏn),
a classification of adenocarcinoma of the prostate by evaluation of the pattern of glandular differentiation; the tumor grade, known as Gleason score, is the sum of the dominant and secondary patterns, each numbered on a scale of 1 to 5.

Gleason score

Oncology A value derived from the Gleason grading system which is the sum of the 2 most predominant histologic patterns seen in prostate CA.

Gleason score

A method of grading malignancy of prostate cancers, based on the pattern of glandular differentiation. Both the dominant and secondary patterns of differentiation are scored on a scale of 1 to 5, and the Gleason score, is the sum of the two scores.

Gleason,

Donald F., U.S. pathologist, 1920–.
Gleason score
Gleason tumor grade - a classification of adenocarcinoma of the prostate.
References in periodicals archive ?
(29) Several studies (103-105) have also showed that the Gleason grade of cancer at the margin is predictive of BCR.
Other preliminary works differentiating low-to-intermediate (Gleason Grade [less than equal to] 3+4) from unfavorable intermediate-to-high risk (Gleason Grade [greater than equal to] 4+3) only achieved 75% classification accuracy (61).
After 78 months of study, high dose FT 15mg single treatment resulted in 73% less surgery or radiotherapy associated with Gleason grade progression, and both doses of FT as a group were overall effective.
Pathological data included pathological T and N stage, biopsy and prostatectomy Gleason grade, and surgical margin status.
When you get a biopsy, a pathologist gives the prostate cells a Gleason grade, which ranges from 1 (most normal) to 5 (most abnormal).
Global Gleason grade groups in prostate cancer: concordance of biopsy and radical prostatectomy grades and predictors of upgrade and downgrade.
DB patient cohort (n=168): from the tumor positive diagnostic biopsy with the highest Gleason grade per patient a single biopsy punch (~1x2 mm) was collected.
Six out of these eight incidental cancers were of Gleason grade 6 while two were of Gleason grade 7.
The aim of our study is to evaluate the effect of additional features such as length, extent and Gleason grade on BCR in the positive SM determined in patients undergoing RP in our clinic.
Few participants knew their prostate cancer stage (10%), Gleason grade (30%), or PSA level (20%) at baseline, yet reported they understood the benefits (60%) and risks (70%) of AS and risks of non-adherence to AS follow-up (90%).
Notification of the significant prognostic difference between prostate carcinomas with Gleason grade 3+4 and 4+3 revealed that treatment decisions using a single Gleason score misdirect the management of patients.
Caption: Figure 1: High-magnification image showing a few glandular lumina with focal areas of loss of glandular differentiation, a pattern consistent with Gleason grade 4 adenocarcinoma of the prostate (H & E, 400x)