(29) Several studies (103-105) have also showed that the Gleason grade
of cancer at the margin is predictive of BCR.
Other preliminary works differentiating low-to-intermediate (Gleason Grade
[less than equal to] 3+4) from unfavorable intermediate-to-high risk (Gleason Grade
[greater than equal to] 4+3) only achieved 75% classification accuracy (61).
After 78 months of study, high dose FT 15mg single treatment resulted in 73% less surgery or radiotherapy associated with Gleason grade
progression, and both doses of FT as a group were overall effective.
Pathological data included pathological T and N stage, biopsy and prostatectomy Gleason grade
, and surgical margin status.
When you get a biopsy, a pathologist gives the prostate cells a Gleason grade
, which ranges from 1 (most normal) to 5 (most abnormal).
Global Gleason grade
groups in prostate cancer: concordance of biopsy and radical prostatectomy grades and predictors of upgrade and downgrade.
DB patient cohort (n=168): from the tumor positive diagnostic biopsy with the highest Gleason grade
per patient a single biopsy punch (~1x2 mm) was collected.
Six out of these eight incidental cancers were of Gleason grade
6 while two were of Gleason grade
The aim of our study is to evaluate the effect of additional features such as length, extent and Gleason grade
on BCR in the positive SM determined in patients undergoing RP in our clinic.
Few participants knew their prostate cancer stage (10%), Gleason grade
(30%), or PSA level (20%) at baseline, yet reported they understood the benefits (60%) and risks (70%) of AS and risks of non-adherence to AS follow-up (90%).
Notification of the significant prognostic difference between prostate carcinomas with Gleason grade
3+4 and 4+3 revealed that treatment decisions using a single Gleason score misdirect the management of patients.
Caption: Figure 1: High-magnification image showing a few glandular lumina with focal areas of loss of glandular differentiation, a pattern consistent with Gleason grade
4 adenocarcinoma of the prostate (H & E, 400x)