Gilbert's syndrome


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Gilbert's syndrome

A form of mild JAUNDICE affecting about 5% of the population, most commonly adolescents and young adults, and often brought on by fasting. Fasting produces ketone bodies that displace BILIRUBIN from its link with the blood protein albumin. The jaundice is due to the excess of bilirubin in the blood. There is yellowing of the skin. Many people affected have no symptoms but there may be loss of appetite, a feeling of sickness and pain in the upper abdomen. The liver function tests are normal but there is a deficiency of a liver enzyme, glucuronyl transferase. The syndrome is sometimes a result of a dominant genetic defect and is also known as benign familial non-haemolytic hyperbilirubinaemia. (Nicolas Augustin Gilbert, French physician, 1858–1927).

Gilbert's syndrome

A mild hereditary form of jaundice.
Mentioned in: Jaundice
References in periodicals archive ?
Bilirubin and beyond: a review of lipid status in Gilbert's syndrome and its relevance to cardiovascular disease protection.
Reduced UGT1A1 gene expression leads to Gilbert's syndrome, Crigler-Najjar syndrome [7], and irinotecan toxicity.
On the other hand, those with congenitally decreased expression of UGT1A1 (which is caused in the majority of Caucasians by homozygosity of the so-called UGT1A1*28 allele) [24] results in mild unconjugated hyperbilirubinemia (Gilbert's syndrome), a condition associated with a decreased risk of cardiovascular diseases [21].
Acute acalculous cholecystitis in children with Epstein-Barr virus infection: a role for Gilbert's syndrome? Int J Inf Dis 2009; 13:e161-e164.
INTRODUCTION: Gilbert's Syndrome (GS) is characterized by mild uncojugated hyperbilirunemia without either the structural liver disease or hemolytic anemia.
Gilbert's syndrome is a genetic (inborn) metabolic condition associated with decreased activity of UGT1A1.
The moderate bilirubin elevation observed in Gilbert's syndrome both lowers the risk of developing coronary heart diseases [8] and accelerates the development of neonatal jaundice during the 2 first days of life [9].
Gilbert's syndrome (GS) is an autosomal recessive disease, which is a benign condition that does not progress into chronic liver disease or fibrosis (1).
QI'M told I have Gilbert's syndrome but not to worry.
with Dr Neil Murray QI'M told I have Gilbert's syndrome but not to worry.