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Etymology: Nicolas A. Gilbert, French physician, 1858-1927
a benign hereditary condition characterized by hyperbilirubinemia and jaundice. See also hyperbilirubinemia of the newborn.
Gilbert's syndromeA form of mild JAUNDICE affecting about 5% of the population, most commonly adolescents and young adults, and often brought on by fasting. Fasting produces ketone bodies that displace BILIRUBIN from its link with the blood protein albumin. The jaundice is due to the excess of bilirubin in the blood. There is yellowing of the skin. Many people affected have no symptoms but there may be loss of appetite, a feeling of sickness and pain in the upper abdomen. The liver function tests are normal but there is a deficiency of a liver enzyme, glucuronyl transferase. The syndrome is sometimes a result of a dominant genetic defect and is also known as benign familial non-haemolytic hyperbilirubinaemia. (Nicolas Augustin Gilbert, French physician, 1858–1927).
A mild hereditary form of jaundice.
Mentioned in: Jaundice
benign hereditary hyperbilirubinemia of humans marked by mild intermittent jaundice and often by fatigue, weakness and abdominal pain. A comparable disease has been identified in mutant Southdown sheep. See inherited photosensitization.