Gilbert's syndrome


Also found in: Acronyms, Wikipedia.

Gilbert's syndrome

Etymology: Nicolas A. Gilbert, French physician, 1858-1927
a benign hereditary condition characterized by hyperbilirubinemia and jaundice. See also hyperbilirubinemia of the newborn.

Gilbert's syndrome

A form of mild JAUNDICE affecting about 5% of the population, most commonly adolescents and young adults, and often brought on by fasting. Fasting produces ketone bodies that displace BILIRUBIN from its link with the blood protein albumin. The jaundice is due to the excess of bilirubin in the blood. There is yellowing of the skin. Many people affected have no symptoms but there may be loss of appetite, a feeling of sickness and pain in the upper abdomen. The liver function tests are normal but there is a deficiency of a liver enzyme, glucuronyl transferase. The syndrome is sometimes a result of a dominant genetic defect and is also known as benign familial non-haemolytic hyperbilirubinaemia. (Nicolas Augustin Gilbert, French physician, 1858–1927).

Gilbert's syndrome

A mild hereditary form of jaundice.
Mentioned in: Jaundice

Gilbert's syndrome

benign hereditary hyperbilirubinemia of humans marked by mild intermittent jaundice and often by fatigue, weakness and abdominal pain. A comparable disease has been identified in mutant Southdown sheep. See inherited photosensitization.
References in periodicals archive ?
Wagner, "Bilirubin and beyond: a review of lipid status in Gilbert's syndrome and its relevance to cardiovascular disease protection," Progress in Lipid Research, vol.
He was a known case of congenital hyperbilirubinemia, Gilbert's syndrome since 2 years.
In Gilbert's syndrome, there is a reduced level of the chemical that deals with the bilirubin.
Rapid allelic discrimination by TaqMan PCR for the detection of the Gilbert's syndrome marker UGT1A1*28.
ANOTHER problem arising out of a metabolic enzyme deficiency is Gilbert's syndrome, which is caused by a high bilirubin count in the bloodstream.
Patients with Gilbert's syndrome, which is present in 7% of Caucasians, show an increased toxicity, mainly diarrhoea and neutropenia, when irinotecan doses exceed 250 mg/[m.
He eventually sold the software company to one of its biggest clients, MD Insurance Services, and took a sabbatical due to the onset of Gilbert's Syndrome, a condition which affects the liver.
It may also be Gilbert's syndrome, which refers to a waste product which builds up in the liver.
Symptoms resembling Gilbert's syndrome (with indinavir).
Has any study been conducted to ascertain whether people with Gilbert's syndrome have a lower incidence of cancer and heart disease?