Giant Cell Reparative Granuloma

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A reactive and focally destructive lesion affecting bone of the jaw, metaphysis and diaphysis of long bones
DiffDx Enchondroma, giant cell tumour, aneurysmal bone cyst
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References in periodicals archive ?
From the archives of AFIP: Imaging of giant cell tumor and giant cell reparative granuloma of bone: Radiologi-pathologic correlation.
Giant cell reparative granuloma affects patients in a wide age range, with most in their third decade.
The differential diagnosis includes an eurysmal bone cysts, chondroblastoma, chondromyxoid fibroma, giant cell reparative granuloma, nonossifying fibroma, Langerhans' cell histiocytosis, synovial sarcoma, and high-grade central osteosarcoma.
Giant Cell Reparative Granuloma was introduced by Jaffe in 1953 to describe an apparently reactive intraosseous lesion of the mandible and maxilla following trauma induced intraosseous hemorrhage and containing prominent giant cells.
Giant cell reparative granuloma, traumatic bone cyst, and fibrous (fibroosseous) dysplasia of the jawbones.
The differential diagnosis for this cytomorphologically benign lesion included villonodular synovitis, giant cell reparative granuloma, and benign chondroblastoma.
Immunoreactivity with p63 was seen in 20 of 23 giant cell tumors of bone (86.9%), 5 of 8 primary aneurysmal bone cysts (62.5%), 10 of 12 chondroblastomas (83.3%), 4 of 4 giant cell reparative granulomas (100%), 2 of 4 osteosarcomas (50%), 1 of 15 tenosynovial giant cell tumors (6.6%), 1 of 6 nonossifying fibromas (16.6%), and 1 of 4 pigmented villonodular synovitides (25%).

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