Niessen et al., "Contribution of bi-allelic germline
MUTYH mutations to early-onset and familial colorectal cancer and to low number of adenomatous polyps: case-series and literature review," Familial Cancer, vol.
variants prioritization, all rare (MAF < 0.01) alterations occurring on the known susceptibility genes of PCC and PGL were considered.
Furthermore, regardless of germline
BRCA status, cancers have high rates of genetic mutation.
At the 2017 Annual Meeting, I will continue that conversation with a plenary on the ongoing proposed guidelines concerning somatic, germline
, curative, and enhancement uses in human beings, and will include Christian insights and purpose that might shape our response.
In the study, Wu and her colleagues isolated and characterized female germline
stem cells from a single transgenic mouse with cells that show green fluorescence when activated by a blue laser.
The panel also called for an ongoing forum to discuss human germline
The technology has the potential to prevent devastating hereditary diseases that are caused by a single defective gene that can be edited out of the germline
and replaced with a correct version.
PARIS, Oct 9 (KUNA) -- A UNESCO panel of scientists, philosophers, lawyers and government ministers has called for a temporary ban on genetic "editing" of the human germline
, calling for a wide public debate on genetic modification of human DNA.
The main concern with CRISPR and similar techniques is that they will be used to perform germline
genetic modifications, which means making changes in a human egg, sperm or embryo.
This is because any manipulation of the germline
of human embryos is potentially heritable.
Food and Drug Administration (FDA) approval of Lynparza (olaparib), the first-in-class PARP inhibitor, and a germline
BRCA test for use as a companion diagnostic for maintenance therapy of high grade serous ovarian cancer.
transcript expression was determined.