germline


Also found in: Dictionary, Encyclopedia, Wikipedia.

germline

 [jerm´līn]
the sequence of cells in the line of direct descent from zygote to gametes, as opposed to somatic cells (all other body cells). Mutations in germline cells are transmitted to offspring; those in somatic cells are not.

germline

or

germ line

(jûrm′līn′)
n.
1. The gamete-producing cells in a sexually reproducing organism, by means of which genetic material is passed on to subsequent generations.
2. The collection or sequence of such cells in an individual and all its descendants.

germ line

, germline
The cells from which the gametes (the ova and sperm) originate.
References in periodicals archive ?
Niessen et al., "Contribution of bi-allelic germline MUTYH mutations to early-onset and familial colorectal cancer and to low number of adenomatous polyps: case-series and literature review," Familial Cancer, vol.
For germline variants prioritization, all rare (MAF < 0.01) alterations occurring on the known susceptibility genes of PCC and PGL were considered.
Furthermore, regardless of germline BRCA status, cancers have high rates of genetic mutation.
At the 2017 Annual Meeting, I will continue that conversation with a plenary on the ongoing proposed guidelines concerning somatic, germline, curative, and enhancement uses in human beings, and will include Christian insights and purpose that might shape our response.
In the study, Wu and her colleagues isolated and characterized female germline stem cells from a single transgenic mouse with cells that show green fluorescence when activated by a blue laser.
The panel also called for an ongoing forum to discuss human germline editing.
The technology has the potential to prevent devastating hereditary diseases that are caused by a single defective gene that can be edited out of the germline and replaced with a correct version.
PARIS, Oct 9 (KUNA) -- A UNESCO panel of scientists, philosophers, lawyers and government ministers has called for a temporary ban on genetic "editing" of the human germline, calling for a wide public debate on genetic modification of human DNA.
The main concern with CRISPR and similar techniques is that they will be used to perform germline genetic modifications, which means making changes in a human egg, sperm or embryo.
This is because any manipulation of the germline of human embryos is potentially heritable.
Food and Drug Administration (FDA) approval of Lynparza (olaparib), the first-in-class PARP inhibitor, and a germline BRCA test for use as a companion diagnostic for maintenance therapy of high grade serous ovarian cancer.