germline

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germline

 [jerm´līn]
the sequence of cells in the line of direct descent from zygote to gametes, as opposed to somatic cells (all other body cells). Mutations in germline cells are transmitted to offspring; those in somatic cells are not.

germline

or

germ line

(jûrm′līn′)
n.
1. The gamete-producing cells in a sexually reproducing organism, by means of which genetic material is passed on to subsequent generations.
2. The collection or sequence of such cells in an individual and all its descendants.

germ line

, germline
The cells from which the gametes (the ova and sperm) originate.
References in periodicals archive ?
If germ-line gene therapy can provide true cures for genetic disorders and prevent transmission of diseasecausing mutations, its development, application, and refinement are not only justified, but imperative.
Our germ-line DNA and those of the great apes--particularly the African forms--are very similar.
Germ-line engineering, with its drastic and open-ended consequences, would be very doubtful.
Both Doudna and Baltimore, as it happens, were part of a group that pondered in 2015 whether to propose an outright moratorium on germ-line editing.
Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells.
In traditional electroporation methods, either levels of transfer have been low with few studies showing germ-line transmission and expression [15] or the device used is no longer commercially available [16].
In 3 percent of the group, healthy-tissue analysis found a potentially detrimental germ-line mutation predisposing patients to cancer.
The British parliament has decided to allow doctors in the United Kingdom to be the first in the world to perform germ-line gene therapy.
Personalis' sequencing depth and coverage uniformity enhances sensitivity for mosaic variants, enabling mosaic detection in probands, as well as germ-line mosaicism detection in the parents for more precise recurrence risk prediction.
Nayak et al., "Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development," Proceedings of the National Academy of Sciences of the United States of America, vol.