gene therapy can provide true cures for genetic disorders and prevent transmission of diseasecausing mutations, its development, application, and refinement are not only justified, but imperative.
DNA and those of the great apes--particularly the African forms--are very similar.
engineering, with its drastic and open-ended consequences, would be very doubtful.
Both Doudna and Baltimore, as it happens, were part of a group that pondered in 2015 whether to propose an outright moratorium on germ-line
transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells.
editing of pigs or dogs offers a line into it," he said.
glh-1, a germ-line
putative RNA helicase from Caenorhabditis has four zinc fingers.
In traditional electroporation methods, either levels of transfer have been low with few studies showing germ-line
transmission and expression  or the device used is no longer commercially available .
In 3 percent of the group, healthy-tissue analysis found a potentially detrimental germ-line
mutation predisposing patients to cancer.
The British parliament has decided to allow doctors in the United Kingdom to be the first in the world to perform germ-line
Personalis' sequencing depth and coverage uniformity enhances sensitivity for mosaic variants, enabling mosaic detection in probands, as well as germ-line
mosaicism detection in the parents for more precise recurrence risk prediction.
Nayak et al., "Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line
development," Proceedings of the National Academy of Sciences of the United States of America, vol.