gentamicin

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Related to Gentamicins: vancomycin

gentamicin

 [jen″tah-mi´sin]
an aminoglycosideantibiotic complex elaborated by bacteria of the genus Micromonospora, effective against many gram-negative bacteria, especially Pseudomonas species, as well as certain gram-positive bacteria, especially Staphylococcus aureus; used as the sulfate salt.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

gen·ta·mi·cin

(jen'tă-mī'sin), Avoid the misspelling gentamycin.
A broad spectrum antibiotic of the aminoglycoside class, obtained from Micromonospora purpurea and M. echinospora, which inhibits the growth of both gram-positive and gram-negative bacteria; the sulfate salt is used medicinally.
Farlex Partner Medical Dictionary © Farlex 2012

gentamicin

(jĕn′tə-mī′sĭn)
n.
A broad-spectrum antibiotic derived from an actinomycete of the genus Micromonospora, used in its sulfate form to treat various infections.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

gentamicin

Garamycin® Infectious disease A broad-spectrum aminoglycoside antibiotic obtained from Micromonospora purpurea Adverse effects Ototoxicity, nephrotoxicity Therapeutic range Peak 5-10 mg/L; trough < 2 mg/L Toxic range Peak > 10 mg/L; trough > 2 mg/L. See Aminoglycosides.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

gen·ta·mi·cin

(jen'tă-mī'sin) Avoid the misspelling gentamycin.
A broad spectrum antibiotic of the aminoglycoside class, which inhibits growth of both gram-positive and gram-negative bacteria; sulfate salt is also used medicinally.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

gentamicin

An aminoglycoside antibiotic used mainly for the treatment of serious GRAM NEGATIVE infections. Otherwise, gentamicin is used topically for external infections, such as those of the eye or ear. In large dosage it can cause TINNITUS, deafness and kidney damage. Recently, gentamycin has been shown to be capable of bypassing a STOP MUTATION and has been shown to be helpful in controlling CYSTIC FIBROSIS and other genetic disorders caused by stop mutations. The drug is on the WHO official list. Brand names are Cidomycin, Garamycin, Genticin and Minims gentamicin. See also PTC124.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

antibiotic 

1. Pertaining to the ability to destroy or inhibit other living organisms.
2. A substance derived from a mould or bacterium, or produced synthetically, that destroys (bactericidal) or inhibits the growth (bacteriostatic) of other microorganisms and is thus used to treat infections. Some substances have a narrow spectrum of activity whereas others act against a wide range of both gram-positive and gram-negative organisms (broad-spectrum antibiotics). Antibiotics can be classified into several groups according to their mode of action on or within bacteria: (1) Drugs inhibiting bacterial cell wall synthesis, such as bacitracin, vancomycin and the β-lactams based agents (e.g. penicillin, cephalosporins (e.g. ceftazidime, ceftriaxone, cefuroxime). (2) Drugs affecting the bacterial cytoplasmic membrane, such as polymyxin B sulfate and gramicidin. (3) Drugs inhibiting bacterial protein synthesis, such as aminoglycosides (e.g. amikacin sulfate, framycetin sulfate, gentamicin, neomycin sulfate and tobramycin), tetracyclines, macrolides (e.g. erythromycin and azithromycin) and chloramphenicol. (4) Drugs inhibiting the intermediate metabolism of bacteria, such as sulfonamides (e.g. sulfacetamide sodium) and trimethoprim. (5) Drugs inhibiting bacterial DNA synthesis, such as nalixidic acid and fluoroquinolones (e.g. ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin). (6) Other antibiotics such as fusidic acid, the diamidines, such as propamidine isethionate and dibrompropamidine. Syn. antibacterial. See antiinflammatory drug; fusidic acid.
Millodot: Dictionary of Optometry and Visual Science, 7th edition. © 2009 Butterworth-Heinemann

gen·ta·mi·cin

(jen'tă-mī'sin)
Broad spectrum aminoglycoside antibiotic that inhibits growth of both gram-positive and gram-negative bacteria.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Gentamicin does not possess a chromophore in its structure and must be derivatized to enable ultraviolet detection.
Our results show that FDNB-derivatized gentamicin components produce different detector responses.
The chemical differences between the gentamicin components are very small, and sufficient separation of the components is difficult to achieve.
It must be emphasized that the gentamicin content in commercial calibration materials is given as the antimicrobial potency of an unknown mixture of at least three components.
The appropriateness of the present method was assessed in a study performed to determine the pharmacokinetics of the gentamicin components in dogs.
The present method can be used to evaluate the accuracy of commonly used nonchromatographic gentamicin assays and to determine the component ratio in unknown samples.
Once versus thrice daily gentamicin in patients with serious infections.
Nephrotoxicity of the constituents of the gentamicin complex.
Gentamicin and gentamicin [C.sub.1] in the treatment of complicated urinary tract infections: comparative study of efficacy tolerance and pharmacokinetics.
Management of intractable Meniere's disease after intratympanic injection of gentamicin. Laryngoscope 2014; 125: 972-8.
Intratympanic gentamicin injection for the treatment of Meniere's disase.
Gentamicin perfusion vestibular response and hearing loss.