gentamicin

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gentamicin

 [jen″tah-mi´sin]
an aminoglycosideantibiotic complex elaborated by bacteria of the genus Micromonospora, effective against many gram-negative bacteria, especially Pseudomonas species, as well as certain gram-positive bacteria, especially Staphylococcus aureus; used as the sulfate salt.

gen·ta·mi·cin

(jen'tă-mī'sin), Avoid the misspelling gentamycin.
A broad spectrum antibiotic of the aminoglycoside class, obtained from Micromonospora purpurea and M. echinospora, which inhibits the growth of both gram-positive and gram-negative bacteria; the sulfate salt is used medicinally.

gentamicin

/gen·ta·mi·cin/ (jen″tah-mi´sin) an aminoglycoside antibiotic complex isolated from bacteria of the genus Micromonospora, effective against many gram-negative bacteria as well as certain gram-positive species; used as the sulfate salt.

gentamicin

(jĕn′tə-mī′sĭn)
n.
A broad-spectrum antibiotic derived from an actinomycete of the genus Micromonospora, used in its sulfate form to treat various infections.

gentamicin

Garamycin® Infectious disease A broad-spectrum aminoglycoside antibiotic obtained from Micromonospora purpurea Adverse effects Ototoxicity, nephrotoxicity Therapeutic range Peak 5-10 mg/L; trough < 2 mg/L Toxic range Peak > 10 mg/L; trough > 2 mg/L. See Aminoglycosides.

gen·ta·mi·cin

(jen'tă-mī'sin) Avoid the misspelling gentamycin.
A broad spectrum antibiotic of the aminoglycoside class, which inhibits growth of both gram-positive and gram-negative bacteria; sulfate salt is also used medicinally.

gentamicin

An aminoglycoside antibiotic used mainly for the treatment of serious GRAM NEGATIVE infections. Otherwise, gentamicin is used topically for external infections, such as those of the eye or ear. In large dosage it can cause TINNITUS, deafness and kidney damage. Recently, gentamycin has been shown to be capable of bypassing a STOP MUTATION and has been shown to be helpful in controlling CYSTIC FIBROSIS and other genetic disorders caused by stop mutations. The drug is on the WHO official list. Brand names are Cidomycin, Garamycin, Genticin and Minims gentamicin. See also PTC124.

antibiotic 

1. Pertaining to the ability to destroy or inhibit other living organisms.
2. A substance derived from a mould or bacterium, or produced synthetically, that destroys (bactericidal) or inhibits the growth (bacteriostatic) of other microorganisms and is thus used to treat infections. Some substances have a narrow spectrum of activity whereas others act against a wide range of both gram-positive and gram-negative organisms (broad-spectrum antibiotics). Antibiotics can be classified into several groups according to their mode of action on or within bacteria: (1) Drugs inhibiting bacterial cell wall synthesis, such as bacitracin, vancomycin and the β-lactams based agents (e.g. penicillin, cephalosporins (e.g. ceftazidime, ceftriaxone, cefuroxime). (2) Drugs affecting the bacterial cytoplasmic membrane, such as polymyxin B sulfate and gramicidin. (3) Drugs inhibiting bacterial protein synthesis, such as aminoglycosides (e.g. amikacin sulfate, framycetin sulfate, gentamicin, neomycin sulfate and tobramycin), tetracyclines, macrolides (e.g. erythromycin and azithromycin) and chloramphenicol. (4) Drugs inhibiting the intermediate metabolism of bacteria, such as sulfonamides (e.g. sulfacetamide sodium) and trimethoprim. (5) Drugs inhibiting bacterial DNA synthesis, such as nalixidic acid and fluoroquinolones (e.g. ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin). (6) Other antibiotics such as fusidic acid, the diamidines, such as propamidine isethionate and dibrompropamidine. Syn. antibacterial. See antiinflammatory drug; fusidic acid.

gen·ta·mi·cin

(jen'tă-mī'sin)
Broad spectrum aminoglycoside antibiotic that inhibits growth of both gram-positive and gram-negative bacteria.

gentamicin, gentamycin

an antibiotic complex elaborated by fungi of the genus Micromonospora, effective against many gram-negative bacteria, especially Pseudomonas species, as well as certain gram-positive bacteria, especially Staphylococcus aureus. As with other aminoglycoside antibiotics gentamicin is ototoxic and nephrotoxic. Used as the sulfate.
References in periodicals archive ?
The appropriateness of the present method was assessed in a study performed to determine the pharmacokinetics of the gentamicin components in dogs.
The present method can be used to evaluate the accuracy of commonly used nonchromatographic gentamicin assays and to determine the component ratio in unknown samples.
Once versus thrice daily gentamicin in patients with serious infections.
Nephrotoxicity of the constituents of the gentamicin complex.
Automated homogeneous immunoassay for gentamicin on the Dimension clinical chemistry system.
Thin-layer chromatographic identification of the gentamicin complex [Note].
Biological activity of the antibiotic components of the gentamicin complex.
Inratympanic gentamicin for Meniere's disease: Short and long-term followup of two regiments of treatment.
Management of intractable Meniere's disease after intratympanic injection of gentamicin.
Intratympanic gentamicin injection for the treatment of Meniere's disase.
Gentamicin perfusion vestibular response and hearing loss.