genetic polymorphism


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Related to genetic polymorphism: Single nucleotide polymorphism

polymorphism

 [pol″e-mor´fizm]
the ability to exist in several different forms.
balanced polymorphism an equilibrium mixture of homozygotes and heterozygotes maintained by natural selection against both homozygotes.
genetic polymorphism the occurrence together in the same population of two or more genetically determined phenotypes in such proportions that the rarest of them cannot be maintained merely by recurrent mutation.
single nucleotide polymorphism (SNP) a genetic polymorphism between two genomes that is based on deletion, insertion, or exchange of a single nucleotide.

ge·net·ic pol·y·mor·phism

the occurrence in the same population of multiple discrete alletic states of which at least two have high frequency (conventionally of 1% or more).

genetic polymorphism

the recurrence within a population of two or more discontinuous genetic variants of a specific trait in such proportions that they cannot be maintained simply by mutation. Examples include the sickle cell trait, the Rh factor, and the blood groups. Compare balanced polymorphism.

genetic polymorphism

or

polymorphism

the presence in a population of two or more MORPHS, produced when different alleles of a gene occur in the same population and the rarest allele is not maintained merely by repeated MUTATION (i.e. has a frequency higher than, say, 0.05%). Such a definition excludes continuously variable characters such as height or skin colour in humans, but the human blood groups are classic examples, where single genes have two or more alleles, producing different antigenic phenotypes. A genetic polymorphism can be maintained by several mechanisms such as heterozygous advantage or FREQUENCY-DEPENDENT SELECTION, and can be stable over several generations (a BALANCED POLYMORPHISM) or may become ‘transient’ as when the environment changes; see, for example, SICKLE-CELL ANAEMIA.
References in periodicals archive ?
High-resolution melting technology for detecting genetic polymorphisms of IL-1b and IL-1Ra in patients with coronary artery disease.
CYP1A1 genetic polymorphisms and uterine leiomyoma risk: A meta-analysis.
Genetic polymorphism of serotonin transporter 5-HTTLPR: involvement in smoking behaviour.
Genetic polymorphism of the calcium sensitive casein in Sicilian Girgentana and Argentata dell'Etna goat breeds.
In this issue, Mitra et al (1) report the biology of human cancer in relation to genetic polymorphisms.
Genetic polymorphism of PON1 at Q192R and L55M modulated paraoxonase activity against paraoxon and not against phenyl acetate.
Partitioning where a genetic polymorphism has dominant or recessive effects with attributable variance of 4% or greater would be practical, as illustrated above.
The genetic polymorphism analyses for the GSTM1 gene was determined by the multiplex polymerase chain reaction (PCR) using the previously described method [19].
Keywords: Genetic polymorphism, Interleukin-12, Irritable bowel syndrome
Substantial amount of genetic polymorphism at msp-3[alpha] have also been reported from Thailand (18), Papua New Guinea (13), Korea (19), Iran (20) and South America (14), thus, supporting high degree of genetic polymorphism observed in the present study.