genetic burden


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ge·net·ic bur·den

the genetic debt due to harmful mutation but as yet undischarged. (In a large population of fixed size every mutation with diminished genetic fitness will eventually become extinct, and depending on the details of inheritance and phenotype, must be paid for by a fixed number of genetic deaths per mutation, the genetic debt.)

genetic burden

1. The number of diseases and deaths that occur as a result of inherited traits.
2. The cost to the genome of mutations or selection pressure that eliminate alleles from it.
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References in periodicals archive ?
One growing problem posed by modern medical technologies is that more people suffering from genetic defects will survive to reproduce, thus increasing the genetic burden for the future.
Hence, the study was undertaken with prime aim to uncover the genetic burden and pathophysiologic machinery of D/BMD by evaluating clinical, biochemical, and genetic indices in Gujarat population.