BRCA1

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Related to Genes, brca1: BRCA2 gene

BRCA1

A gene on chromosome 17q21, which encodes a protein that plays a role in maintaining genomic stability and acts as a tumour suppressor. It combines with other tumour suppressors, DNA damage sensors and signal transducers to form a large multi-subunit-protein complex known as the BRCA1-associated genome surveillance complex (BASC), which associates with RNA polymerase II and histone deacetylase complexes, thus playing a role in transcription, DNA repair of double-stranded breaks and recombination. BRCA1 mutations cause 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers.

BRCA1

Molecular oncology A large tumor suppressor gene on chromosome 17 which is linked to breast, ovarian, prostate and other CAs; Pts with BRCA1 represent 5% of all breast CAs; ♀ with BRCA1 have an 85% chance of developing breast CA before age 65; mutations of BRCA1 are common in Ashkenazi Jews Lab BRCA1 and BRCA2 are part of some commercial diagnostic labs' genetic services. See Tumor suppressor gene.
References in periodicals archive ?
By 1990, the group had significantly narrowed down the location of one of the key genes, BRCA1. The consortium reported that it was "very close" to finding BRCA1, with one researcher declaring that "it will probably be luck, whoever finds it."
Approximately 5-10% of breast cancer cases ate the result of inherited mutations, or alterations in breast cancer susceptibility genes, BRCA1 and BRCA2.
What's now known about one of the major breast and ovarian cancer genes, BRCA1, exemplifies several of these situations.
Faults in two other genes, BRCA1 and BRCA2, have already been identified as dramatically increasing the chance of developing the disease.
Rohlfs developed and evaluated protein truncation analysis and allele-specific assays for the detection of disease-causing mutations in the breast and ovarian cancer genes, BRCA1 and BRCA2.
who reaches age 85 will develop breast cancer at some time in her life.[5] More than 180,000 women in this country are afflicted with breast cancer every year.[6] Of these cases, an estimated 5%-10% result from an inherited mistake or mutation in one of at least two genes.[7] One of these genes, BRCA1, was identified in 1994 and is thought to be a tumor suppressor gene that codes for a protein capable of negatively regulating tumor growth.[8]
Scientists at the University of Nottingham focused on inherited cancer causing genes, BRCA1 and BRCA2, as they cause up to 10 percent of breast cancers that are more often fatal than non-genetic tumours.
In the 1990s the discovery of the breast cancercausing genes, BRCA1 and BRCA2, gave us insight into how the DNA we inherit affect the diseases we get.
The study, involving 979 men with prostate cancer and 1251 men without the disease, looked at whether participants carried mutations for either of two genes, BRCA1 and BRCA2.
It is only in the past 10 years that scientists have identified faults on two genes, BRCA1 and BRCA2, that are linked to breast and ovarian cancer.