By 1990, the group had significantly narrowed down the location of one of the key genes, BRCA1
. The consortium reported that it was "very close" to finding BRCA1, with one researcher declaring that "it will probably be luck, whoever finds it."
Approximately 5-10% of breast cancer cases ate the result of inherited mutations, or alterations in breast cancer susceptibility genes, BRCA1
What's now known about one of the major breast and ovarian cancer genes, BRCA1
, exemplifies several of these situations.
Faults in two other genes, BRCA1
and BRCA2, have already been identified as dramatically increasing the chance of developing the disease.
Rohlfs developed and evaluated protein truncation analysis and allele-specific assays for the detection of disease-causing mutations in the breast and ovarian cancer genes, BRCA1
who reaches age 85 will develop breast cancer at some time in her life. More than 180,000 women in this country are afflicted with breast cancer every year. Of these cases, an estimated 5%-10% result from an inherited mistake or mutation in one of at least two genes. One of these genes, BRCA1
, was identified in 1994 and is thought to be a tumor suppressor gene that codes for a protein capable of negatively regulating tumor growth.
Scientists at the University of Nottingham focused on inherited cancer causing genes, BRCA1
and BRCA2, as they cause up to 10 percent of breast cancers that are more often fatal than non-genetic tumours.
In the 1990s the discovery of the breast cancercausing genes, BRCA1
and BRCA2, gave us insight into how the DNA we inherit affect the diseases we get.
The study, involving 979 men with prostate cancer and 1251 men without the disease, looked at whether participants carried mutations for either of two genes, BRCA1
It is only in the past 10 years that scientists have identified faults on two genes, BRCA1
and BRCA2, that are linked to breast and ovarian cancer.